Korea University Medical Center

School-age Children as the Dominant Source of Inter-seasonal Influenza Circulation in the Republic of Korea, 2022–2025

Background: Influenza circulates at low levels during summer inter-seasonal periods, potentially bridging consecutive epidemics. Which age groups contribute most to this residual circulation is not well characterized. Methods: We analyzed weekly influenza detection rates from the...

Radiologic capsular abnormalities on shoulder MRI: associations with rotator cuff and biceps tendon tears and implications for the diagnosis of adhesive capsulitis

Capsular abnormality on shoulder MRI may suggest adhesive capsulitis, but similar findings can occur in patients with other shoulder pathologies such as rotator cuff tears. This study investigated the clinical and imaging factors associated with radiologic capsular abnormality (R...

The double barrier: coronavirus disease 2019 and cervical cancer screening disparities among women with disabilities in South Korea: a nationwide cohort study

The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems, potentially exacerbating pre-existing health disparities. Women with disabilities face structural barriers to healthcare that may be intensified during public health crises....

Prognostic implications of the duration of continuous kidney replacement therapy in 3-month survivors of acute kidney injury: findings from the LINKA cohort

The duration of continuous kidney replacement therapy (CKRT) represents a complex clinical surrogate reflecting the severity of systemic illness, the rate of metabolic recovery, and clinical decision-making regarding treatment discontinuation. The effect of CKRT duration on long-...

Lobular carcinoma as a spectrum: resolving the gray zone between morphology, E-cadherin, and CDH1

Invasive lobular carcinoma (ILC) is characterized by E-cadherin loss resulting from CDH1 inactivation, but discordance among morphology, immunohistochemistry (IHC), and molecular findings can complicate diagnosis. We integrated histology, IHC, DNA sequencing, and whole-transcript...

Extended treatment duration and recurrence in successfully treated drug-susceptible pulmonary tuberculosis with cavity on chest radiograph

Background Cavity on chest radiograph is recognized as an independent risk factor for recurrence in pulmonary tuberculosis (TB), but evidence supporting extended treatment in these patients remains limited, particularly in real-world data from Korea. Methods We performed a retros...

Preferences and reasons for clothing colors in women patients and survivors of breast cancer in Korea

Purpose Clothing color can affect the psychological aspects in female patients and survivors of breast cancer; however, little is known regarding their preferences and reasons for choosing specific clothing color. This study aimed to explore the factors influencing their clothing...

Differential Diagnosis of Lung Cancer Using Artificial Intelligence-Based Extracellular Vesicle Analysis: A Pilot Study

Abstract In cancer diagnosis, liquid biopsy is a minimally invasive method, yet its diagnostic performance is constrained by insufficient sensitivity and restricted blood biomarkers. Therefore, the use of additional invasive methods is unavoidable to identify cancer-specific info...

Changing Clinical Characteristics, Diagnostic Patterns, and Outcomes of Tuberculosis in South Korea: The Korean Tuberculosis Cohort, 2019-2024

BACKGROUND: Tuberculosis (TB) remains a public health concern in South Korea despite declining national notifications. We evaluated temporal changes in clinical characteristics, diagnostic patterns, and treatment outcomes in the Korean Tuberculosis Cohort (KTBC) from 2019 to 2024...

Stereotactic body radiation therapy for hepatocellular carcinoma: 2026 expert consensus-based practical recommendation of the Korean Liver Cancer Association

Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...

Pulmonary surfactant-based inhalable nanoparticles for folate receptor-targeted delivery and macrophage reprogramming in lung cancer

Abstract Background Lung cancer remains a leading cause of cancer-related death, and chemotherapy is often limited by systemic toxicity and insufficient drug accumulation in lung tumors. Inhalable nanomedicine offers a route to address these limitations, but nanoparticle systems...

Effect of silane treatment and resin cement type on bond strength to three-dimensional printed restorative resin: an in vitro experimental study

Objectives: This study aimed to evaluate the shear bond strength (SBS) of different resin cements to three-dimensional (3D)-printed restorative resins and to investigate the effects of silane treatment and substrate type on bonding performance. Methods: Four resin cements-three s...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

P1.117. Photodynamic Therapy for Esophageal Cancer: A Single-Center Experience With Clinical Outcomes

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Photodynamic therapy (PDT) is a minimally invasive local treatment that selectively destroys malignant cells with minimal systemic toxicity. It has emerged as an alternative therapeutic optio...

Performance metrics in systematic reviews and meta-analyses of artificial intelligence-based prediction models for children and pregnant women: protocol for an umbrella review

Artificial intelligence (AI) has shown significant promise in medical diagnostics. However, children and pregnant women represent “vulnerable populations” often underrepresented in large-scale training datasets. This paper summarizes a protocol for an umbrella review aiming to id...

Evaluating Immunotherapy Outcomes in Elderly Patients with Extensive-Stage Small-Cell Lung Cancer (KCSG LU23-15)

PurposeChemoimmunotherapy has improved outcomes in extensive-stage small-cell lung cancer (ES-SCLC), but its benefit in older adults remains uncertain because this population is underrepresented in clinical trials.We evaluated the real-world efficacy of first-line atezolizumab pl...

Unipolar Barrier Near‐Infrared 2D Photodetectors for 3D Image Sensors

ABSTRACT Photodetectors sensitive to the near‐infrared (NIR) range are of great importance for applications in machine vision, autonomous driving, and three‐dimensional (3D) imaging under low‐light or adverse weather conditions. Recently, two‐dimensional (2D) semiconductors have...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Blood viscosity is associated with smoking status rather than the presence of chronic obstructive pulmonary disease: findings from the Korea COPD Subgroup Study (KOCOSS)

Abstract Background The relationship between smoking and blood viscosity is well established. However, the role of blood viscosity in the development of chronic obstructive pulmonary disease (COPD) and its impact on lung function decline remains unclear. Therefore, we aimed to in...

Psychedelic-informed Therapeutics and Functional Decoupling: Toward Experience-independent Rapid-acting Antidepressants

Major depressive disorder remains a leading cause of global disability, and many patients show limited response to conventional antidepressants.Increasing evidence suggests that a substantial subgroup exhibits chronic low-grade inflammation, which may constrain synaptic plasticit...