Korea Research Institute of Bioscience and Biotechnology

Deciphering the Redox-Mediated Interplay Along the Gut–Lung–Brain Axis: Macrophage and Microglia Hyperactivation in Systemic Inflammation

Emerging paradigms in systemic immunology have illuminated the intricate, bidirectional communication networks linking distant organ systems, which are conceptualized as the gut–lung–brain axis. The homeostasis of this anatomical triad is primarily disrupted by localized and syst...

Polyacetylenes from Lobelia chinensis with Dermal Papilla Cell Proliferative Activity and Their Enhanced Production through Elicitation

Abstract Lobelia chinensis is a medicinal plant containing a wide variety of bioactive constituents. In the present study, a 50% methanol extract of L. chinensis significantly promoted the proliferation of human dermal papilla (DP) cells. The n-BuOH fraction was identified as the...

In situ antibacterial thermosensitive hydrogel as a versatile platform for diabetic wound therapy and molecular monitoring

Chronic diabetic wounds are difficult to manage because of persistent inflammation, impaired tissue regeneration, and high infection risk under hyperglycemic conditions. Microbial colonization further aggravates inflammatory responses and disrupts the normal progression of wound...

Label‐Free YaxAB Nanopore Fingerprinting of Cancer‐Associated Single‐Residue Bcl‐xL Variants

Resolving cancer-associated protein variants remains difficult when variants share similar molecular masses and folded structures. Conventional assays often require labels or provide ensemble-averaged readouts, limiting their ability to resolve subtle variant differences. Here, a...

Metabolomic profiling and biomedical potential of adventitious roots derived from a 150-year-old mountain ginseng

Panax ginseng Meyer, sometimes known as Asian ginseng or Korean ginseng, is an important medicinal herb used in traditional medicine and health foods in Korea, China, and Japan. Ginsenosides, also known as saponins, are found in ginseng roots along with polysaccharides, peptides,...

Value and spatial preferences guide habitual reaching and manual object selection in primates

Habits are automatic actions shaped by prior experience, enabling efficient and fast responses in stable environments. While habitual gaze rapidly directs the eyes toward valuable objects, the mechanisms underlying habitual manual choice for reaching and grasping remain unclear....

CTG repeat expansion disrupts RNA splicing and WNT/BMP–HOX transcriptional programs in patient-derived models of myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by CTG repeat expansion in the DMPK gene, resulting in the formation of nuclear CUG RNA foci, sequestration of MBNL1, and widespread defects in RNA processing. Here, we investigated the molecular consequences of C...

APC/C−CDH1 suppresses AROS-mediated protection against DNA damage-induced senescence by ubiquitination

Anaphase-promoting complex/cyclosome (APC/C) regulates the cell cycle by destruction of target proteins ubiquitination. However, understanding the control of APC/C has remained elusive. We identify APC2, the catalytic core subunit of APC/C, as a binding partner of active regulato...

UPLC-QTOF/MS-based profiling of major metabolites associated with the inhibition of adipocyte lipid accumulation in different parts and cultivars of Crataegus pinnatifida Bunge

This study evaluated the inhibitory effects of extracts from different parts of Crataegus pinnatifida, including fruit, leaf, twig, and root, on lipid accumulation in adipocytes and characterized their major metabolites using ultra-performance liquid chromatography coupled with q...

Rethinking non-human primate models for emerging viral infections after COVID-19

Non-human primates (NHPs) retain particular value in emerging viral infection research when questions require integrated analysis of systemic viral kinetics, protective immunity, tissue pathology, or longitudinal outcomes. However, their cost, limited availability, specialized hu...

Co-evolutionary pathways of synthetic biology regulation: A comparative analysis of major countries and Korea's strategic legislation

The convergence of synthetic biology and artificial intelligence is widening the gap between technological advancement and existing regulatory frameworks - a phenomenon known as regulatory lag. As global competition intensifies to capture a synthetic biology market projected to r...

The generative rearchitecture of antibody engineering shifts empirical discovery into intentional design

Abstract Generative AI is reshaping antibody engineering by transitioning from empirical screening toward more specification-driven design, potentially expanding the accessible target landscape. While front-loading developability criteria helps streamline discovery timelines, dat...

A refined MASH–HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression

Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading driver of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking metabolic stress, chronic inflammation and tumorigenesis remain poorly understood. Here we established a metabo...

WDR23 prevents bone loss by promoting autophagic degradation of TRAF6 in osteoclastogenesis

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a pivotal adaptor molecule in the receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) signaling pathways, which are essential for osteoclastogenesis. In this study, we identified WD40 repeat-containin...

Efficacy of Polyhexamethylene Biguanide Antibacterial Gel Coating of Orthopedic Implants in Infection Control and Immune Modulation

ABSTRACT With the growth of the older adult population and the increasing incidence of traumatic injuries, the use of orthopedic devices has risen significantly. However, in addition to material‐related limitations, one of the most serious challenges associated with these devices...

Dual-mode SOX2 regulation by miR-150 via mRNA suppression and autophagy controls stem cell fate

Autophagy plays a critical role in maintaining cellular homeostasis and regulating stem cell fate. Although microRNAs (miRNAs) are being increasingly recognized for their ability to modulate autophagy and pluripotency in human pluripotent stem cells (hPSCs), the underlying molecu...

Engineering a terephthalate-responsive PobR biosensor for discovering PET-degrading microbes via cell-to-cell communication

Abstract Background Poly(ethylene terephthalate) (PET) is one of the most widely used synthetic plastics, yet its environmental accumulation continues to outpace effective recycling. Although PET-degrading enzymes and microorganisms have been reported, discovery of new PET-degrad...

A plasmid-associated immunoglobulin-binding protein in Acinetobacter baumannii

Background A cinetobacter baumannii is a critical global health threat due to multidrug resistance and high mortality. Although antimicrobial resistance mechanisms are well characterised, the virulence determinants that drive severe infections remain poorly understood. Methods We...

Lipid Mediators Derived from Docosahexaenoic Acid Alleviate Periodontal Inflammation and Alveolar Bone Loss in Periodontitis Associated with Suppression of the NF-κB and STAT3 Signaling Pathways

Background: Lipid mediators (LM), comprising 17S-hydroxy-docosahexaenoic acid, resolvin D5, and protectin DX in a ratio of 3:47:50, were naturally generated from docosahexaenoic acid by soybean lipoxygenase and exhibit potent anti-inflammatory activities. However, their therapeut...

Transporter Interactionsof Methoxyflavones and Their In Vivo PharmacokineticImplications

Abstract Flavonoids are widely consumed dietary polyphenols that modulate drug disposition via membrane transporters. Increasing attention has been paid to methoxyflavones (MeO-FLVs) because methoxylation can increase membrane permeability and metabolic stability, potentially ele...