Koç University

Max Weight Independent Set in sparse graphs with no long claws

For graphs \(G\) and \(H\) , we say that \(G\) is \(H\) -free if it does not contain \(H\) as an induced subgraph. Already in the early 1980s Alekseev observed that the Max Weight Independent Set problem ( MWIS ) remains NP -hard in \(H\) -free graphs, unless every component of \...

Rethinking Haber–Bosch: Decentralized Green Ammonia Synthesis by Intensification and Electrification

Abstract This review article outlines the current state-of-the-art in small-scale ammonia (NH3) production via mild Haber-Bosch synthesis. Attention is devoted to addressing functional materials and process challenges and opportunities to intensify the thermo-catalytic synthesis...

Dental Implants After Head and Neck Radiotherapy: From Chronological Waiting Rules to Implant-Bed-Specific Risk Stratification

Dental implant-supported rehabilitation is a key component of functional survivorship care for patients with head and neck cancer (HNC) treated with radiotherapy (RT). Despite its importance, implant outcomes in this population are frequently interpreted through simplified paradi...

Molecular Glue Degraders in Early Development for Cancer Therapy

Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein-protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are...

Single-Port Robotic Thoracic Surgery via Intercostal Approach: First Series from Turkey

Abstract Single-port (SP) robotic platforms aim to reduce surgical trauma by allowing all instruments through a single incision. In thoracic surgery, SP experience has been reported mainly via subxiphoid or subcostal routes, whereas the intercostal approach and heterogeneous case...

Multimode fiber laser cavities as nonlinear optical processors

Optical computing provides a promising path toward energy-efficient machine learning, yet implementing nonlinear transformations without complex electronics or high-power sources remains challenging. Here, we demonstrate that continuous-wave multimode fiber laser cavities can fun...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Real-World Outcomes of Second-Line Chemotherapy in Metastatic Urothelial Carcinoma

Second-line chemotherapy is widely used in metastatic urothelial carcinoma after progression on first-line platinum-based therapy, but its independent contribution to survival, as opposed to selection of healthier patients, remains unclear. In this multicenter retrospective cohor...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...

Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members

Study Design Cross-sectional survey. Objective Outcomes research has significantly shaped patient management in spine deformity care, while the dissemination of research remains a challenge. To guide future research directions, this study surveyed AO Spine members to identify the...

Learning anatomy through multiple modalities: medical students’ learning experiences and outcomes

Anatomy education increasingly incorporates digital and simulation-based resources alongside cadaver-based instruction; however, uncertainty remains regarding how different modalities can be integrated to support both cognitive learning and emotional adaptation. This study compar...

Surgical outcomes of constrictive pericarditis and exploratory associations with inflammatory features: a 17-year single-center experience

Constrictive pericarditis (CP) remains a challenging disease with evolving etiological patterns and increasing emphasis on phenotype-based management. Pericardiectomy is the definitive treatment for CP. However, contemporary data on the etiological spectrum and the clinical relev...

An attempt to establish a novel mechanism to tackle illegal football broadcasting on the internet: the extensive authority of the Turkish football federation at the expense of violating constitutional law principles

Abstract Illegal broadcasting of live sports content has been a challenge that remains unresolved. Considering the dynamic nature of such unlawful activities, tackling illegal sports broadcasting in a timely and effective manner is of utmost importance for IP enforcement on the I...

Comparison of Direct Oral Anticoagulants and Low-Molecular-Weight Heparins in Cancer Patients with Nonvalvular Atrial Fibrillation: Insights from a Single-Center Experience

BACKGROUND: Atrial fibrillation (AF) is frequently encountered in patients with cancer and poses challenges for anticoagulant management. The present study was conducted to compare clinical outcomes associated with direct oral anticoagulants (DOACs) and low-molecular-weight hepar...

The effect of pulmonary nodule presence on disease severity and course in ANCA-associated vasculitis: a multicenter cohort study

Pulmonary nodules are common in ANCA-associated vasculitis (AAV), but their clinical relevance remains unclear. This study assessed the influence of pulmonary nodules and radiological features on clinical characteristics and outcomes in AAV. In this multicenter retrospective coho...

Ontological dissonance and memory orders: Russia and geopolitical identity struggles in the Balkans

This paper examines how different Balkan states manage ontological dissonance vis-à-vis Russia’s mnemonic power, the ability to define what and how to remember, as observed through shifts in state memory regimes since Russia’s internationally unrecognized annexation of Crimea in...

Nurse Practitioner Roles and Contributions in a Mobile Health Clinic for People Experiencing Homelessness

ABSTRACT Aim To present a descriptive, practice‐based account of a nurse practitioner‐led mobile health clinic serving individuals experiencing homelessness, guided by the PRIME‐NP framework. Background Homelessness is associated with health inequities and limited access to care....

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

Evidence to guide the treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with...

Effect of BMI on efficacy of androgen receptor pathway inhibitors in patients with metastatic hormone-sensitive prostate cancer

Background Body mass index (BMI) has been associated with improved outcomes in several malignancies, including prostate cancer. However, the impact of BMI on treatment efficacy, particularly with androgen receptor pathway inhibitors (ARPIs), in metastatic hormone-sensitive prosta...