Koç University

Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy

An urgent requirement in chimeric antigen receptor (CAR) immune cell therapy [e.g., CAR–natural killer (NK) cells] for solid tumors is to engineer the cells for precise tumor targeting. Meanwhile, medical microrobots can be navigated toward specific target sites using external ma...

Scalable low-thermal-budget fabrication of suspended silicon nanowire devices

Silicon nanowires (Si NWs) are versatile one-dimensional building blocks for gas and biochemical sensors, MEMS/NEMS physical transduction platforms, and integrated electronic devices because of their high surface-to-volume ratios and compatibility with semiconductor processing. A...

HIV transmission behaviors, detectable HIV-RNA and curable STI prevalence among Ugandan men with HIV with reproductive goals, with and without infertility experiences

Many men with HIV (MWH) want children. MWH with unmet reproductive goals may prioritize conception over preventing HIV/STI transmission. Therefore, we evaluated whether MWH with unmet versus met reproductive goals were more likely to have detectable HIV-RNA or STIs, and explored...

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-sp...

Beyond permission: Reconsidering anatomy education through a contemporary Islamic fatwa in Türkiye

Abstract The ethical use of human body donors in anatomy education is shaped by scientific and professional standards as well as cultural, societal, and religious contexts. In Türkiye, body donation remains limited, and anatomical institutions continue to rely partly on unclaimed...

Associations Between Physical Activity Measurement Modality and Gut Microbiome in Breast Cancer Survivors

Background/Objectives: Physical activity (PA), physiological fitness, and the gut microbiome have each been linked to health outcomes among breast cancer survivors (BCS); however, these associations have been inconsistent. Few studies have directly compared the associations of se...

Vascular device practices in extremely preterm infants: an international cross-sectional survey

Abstract Objective To explore global practices in vascular device selection, securement, and monitoring for extremely preterm infants, and to assess regional variation. Study design A web-based cross-sectional survey was completed by one respondent per neonatal unit. Result We re...

Unified analytical thermal modeling of laser powder bed fusion: Integration of semi-infinite heat conduction and boundary effects

This article proposes a novel implementation of a classic analytical thermal model for a moving heat source in bounded regions, building on the exact solution for the temperature distribution arising from a stationary heat source in a wedge with zero-flux boundaries. With the imp...

Systemic Retinoids in Cutaneous T-Cell Lymphoma: A Scoping Review of Clinical Use and Evidence Gaps

Systemic retinoids are ubiquitously used in cutaneous T-cell lymphoma (CTCL), often in combination with skin-directed or systemic therapies, yet their role within contemporary multimodal treatment strategies has not been comprehensively synthesized. We conducted a PRISMA-ScR-guid...

miR-548ah-3p suppresses ovarian cancer stemness and therapeutic resistance through network-level signaling reprogramming within a distinct alternative polyadenylation landscape

Abstract Therapeutic resistance and cellular plasticity remain major challenges in high-grade serous ovarian cancer (HGSOC), yet the RNA-mediated mechanisms sustaining stem-like states remain incompletely understood. Here, we investigated microRNA-driven signaling reprogramming a...

Single-Session Versus Hypofractionated Gamma Knife Radiosurgery for Large Parasagittal Meningiomas: A Retrospective Comparative Study

Background/Objectives: Large parasagittal meningiomas (PSMs) present significant surgical challenges due to their proximity to the superior sagittal sinus, and the optimal radiosurgical strategy for large tumors remains debated. This study compared local control (LC) and treatmen...

Efficacy and Safety of Incremental Hemodialysis: A Systematic Review and Meta‐Analysis

ABSTRACT Hemodialysis, the most commonly employed renal replacement therapy in end‐stage kidney disease, prescriptions have long been standardized as thrice‐weekly at full‐dose; however, HD implementation is not without major complications. Incremental HD modalities are developed...

Provenance and exchange networks of Mycenaean pottery from Tell Atchana/Alalakh, Southern Türkiye: A comparative ICP-MS and petrographic investigation

This paper presents the results of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and petrographic analyses conducted on Mycenaean pottery assemblages—specifically Late Helladic (LH) IIIA2 and LH IIIC-style ceramics—recovered from the Late Bronze Age II and Early Iron Age...

Propagation of Immigration Shocks through Firm-to-Firm Trade Networks,

Abstract This paper investigates the extent to which an immigration shock to a region propagates through supply chains. Using the unexpected arrival of Syrian refugees, who are densely concentrated in border regions of Turkey, we estimate how firms across the country are affected...

Beyond the handshake: persistent confrontation in Turkish-Greek diplomatic discourse after the 2016 coup

When rival states move toward rapprochement, does the routine discourse of their foreign-policy bureaucracies actually change? This article examines that broader puzzle through a quantitative text analysis of Turkish-Greek relations based on Turkish Ministry of Foreign Affairs st...

Rethinking Preoperative MRI in Early Breast Cancer: Who Truly Benefits?

Objective: In light of existing evidence on the use of preoperative magnetic resonance imaging (MRI) in breast cancer (BC) patients undergoing upfront surgery, this study evaluated whether adding MRI to conventional imaging improved the definition of disease extent, subsequent su...

Beyond rare gases: Cooling of trapped BN− ions by H2 molecules

Quantum dynamics of collisional cooling of the BN- anion in a cold trap is carried out by using the ortho- and para-H2 molecules as a buffer gas. The calculations are performed using the full four-dimensional interaction potential energy surface in which both BN- and H2 are treat...

Transperitoneal Spiralized Rectus Abdominis Muscle Flap for Total Vaginal Reconstruction

Total vaginal reconstruction remains a significant surgical challenge in patients with altered pelvic anatomy due to oncologic resection, radiation, trauma, or congenital absence. Traditional flap options often present limitations in terms of bulk, reach and donor site morbidity....

Repulsive serial dependence in visual working memory modulated by target fidelity

Visual representations are open to systematic functional biases. In visual working memory, representations of serially presented stimuli can either attract or repel each other. Such serial dependence biases are thought to reflect adaptive Bayesian processes yielding optimal perce...

Triggering receptors expressed on myeloid cells (TREM-1) and TREM-2 as predictors of pathological complete response to neoadjuvant therapy in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, characterized by early metastasis, high recurrence rates, and limited targeted therapy options. Pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) is a well-establi...