Kitasato University

Adsorption of Chiral Ir(III) Complexes on Clay Nanosheets: Optical-Purity-Dependent Packing and Amplified Circularly Polarized Luminescence

Abstract Controlling the spatial distribution of photoluminescent molecules within constrained microenvironments remains a fundamental challenge in enhancing their photophysical properties. Herein, we demonstrate that the differential adsorption behavior of enantiopure and racemi...

2026 revised CVIT clinical expert consensus on drug coated balloons for coronary artery disease

Abstract Drug-coated balloons (DCBs) are attracting attention as a therapeutic alternative to drug-eluting stents (DES) in percutaneous coronary interventions. DCB technology allows direct delivery of antiproliferative drugs to the vessel wall without implantation of a permanent...

Synthesis, Structures, and Properties of Cyclopenta‐Fused Anthra[1,2‐ a ]anthracene Derivatives as New Polycyclic Aromatic Compounds

Three new cyclopenta-fused (CP) polycyclic aromatic compounds were synthesized from anthra[1,2-a]anthracenes by direct C─C bond formation in the internal region by Scholl reaction or by benzo fusion at the external corner through Pd-catalyzed cyclization. X-ray analysis and DFT c...

Predicting the distribution of 16 tick species in Japan and its association with the occurrence of tick-borne diseases

Tick-borne diseases are a significant public health threat. Since the infection risk is directly associated with spatial variations of vector ticks, comprehensive data on their distributions are crucial for disease preparedness. Nevertheless, the difficulty of conducting field su...

The uniqueness of covers of widely generalized line graphs

As a natural generalization of line graphs, Hoffman line graphs were defined by Woo and Neumaier. Especially, Hoffman line graphs are closely related to the smallest eigenvalues of graphs, and the uniqueness of strict covers of a Hoffman line graph plays a key role in such a stud...

Clinical impact of stage-specific central sensitization-related symptoms in hip osteoarthritis secondary to acetabular dysplasia

Abstract This study aimed to compare the characteristics of central sensitization (CS)-related symptoms between mild and severe hip osteoarthritis (OA) secondary to acetabular dysplasia and to clarify their associations with hip pain. A total of 116 patients with unilateral hip O...

Real‐World Landscape of BRCA Deleterious Alterations in Advanced Prostate Cancer: Insights From a Nationwide Genomic Database

ABSTRACT Background The clinical characteristics of BRCA1 and BRCA2 ( BRCA ) deleterious alterations in advanced prostate cancer—considering age, family history, co‐occurring gene alterations, and variant type—remain incompletely understood in patients undergoing tumor‐only panel...

Circularly Polarized Electroluminescence and Spin‐Polarized Carrier Transport in Chiral‐Doped Polymer Films

ABSTRACT Circularly polarized electroluminescence (CPEL) based on spin‐dependent light emission is of considerable interest for functional chiral optoelectronics and spin‐photonic applications. Here we report CPEL from devices incorporating achiral poly(9,9‐dioctylfluorene) (PFO)...

Item-level analysis and network analysis of the functional independence measure cognitive items at discharge after acute stroke

Purpose This study characterized item-level profiles and inter-item relationships of the five Functional Independence Measure (FIM) cognitive items at discharge after acute stroke, using clinically anchored coding and network analysis.Methods Discharge FIM cognition scores were r...

A National Survey of Nurses' Knowledge and Nursing Practices Regarding Cancer Therapy–Related Cardiac Dysfunction Among Patients With Breast Cancer in Japan

ABSTRACT Aim Developing effective nursing support for cancer therapy–related cardiac dysfunction (CTRCD) in patients with breast cancer requires understanding nurses' knowledge and nursing practices regarding CTRCD. This study elucidated these aspects among Certified Nurse Specia...

Person-Period survival models with time-dependent covariates: a comparative simulation and pharmacovigilance case study

Person-period data are widely used in time-to-event analyses with time-dependent covariates when covariate histories are summarized over discrete intervals. In pharmacovigilance databases, cumulative drug exposure often requires reconstruction from irregular dosing records, requi...

Community periodontal index based screening findings and healthcare expenditures: a 7-year cohort study of male employees in Japan

Abstract Background The global economic burden of dental diseases, particularly periodontitis, is substantial, with growing evidence linking these conditions to systemic diseases such as diabetes and cardiovascular diseases. Although international studies have demonstrated that p...

Look good to die or look poor to survive: antler properties in a malnourished sika deer population

Abstract The antlers of male deer function as visual displays of power, and as physical weapons to stag opponents, thereby functioning as determinants of social rank. Thus, stags with long and “magnificent” antlers would have more chances for reproductive success. Cervid antlers...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Outcomes of Asian and Caucasian patients with type A aortic intramural haematoma: a multicentre registry analysis

Background Outcomes of aortic intramural haematoma (IMH) have shown disparities between Asian and Caucasian patients. We evaluated the heterogeneity of treatment effects in Asian and Caucasian patients with type A IMH. Methods This multicentre registry included individual patient...

Structural origin of the strong effect of attraction on bulk viscosity in simple liquids

The effects of pairwise attraction and three-body interactions (Axilrod-Teller-Muto triple-dipole potential) on bulk viscosity, compared with shear viscosity, were investigated using molecular dynamics simulations, with particular focus on the underlying structural dynamics. Our...

Efficacy of Cold-Stimulus Interventions for Thirst Management in Adult Postoperative Patients: A Systematic Review Protocol

Background/Objectives: Postoperative thirst is a common and distressing symptom among surgical patients; however, standardized management guidelines remain limited. Oral care interventions using cold stimulation (e.g., ice chips, popsicles, and menthol-infused products) may relie...

Long-term effects of cognitive-behavioral therapy for adults with ADHD: results from an 8-year randomized controlled trial follow-up

Abstract Background To evaluate the provisional long-term durability of group cognitive behavioral therapy (CBT) benefits 8 years post-baseline and to explore tentative associations between digital booster engagement and the maintenance of treatment gains in adults with ADHD. Met...

High-sensitivity Cardiac Troponin I Changes Following Subcutaneous Needle Puncture, Restraint, and Venipuncture in Cynomolgus Monkeys

Background/Aim: Cardiac troponin I (cTnI) is a sensitive biomarker of myocardial injury in which procedure-related stress may cause mild, non-injury-related increases. This study aimed to characterize procedure-related variability of high-sensitivity cTnI and related biomarkers i...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...