Kirby Institute

Engineering Antibody Evolution: Germline‐Targeting HIV Vaccines Reach a Turning Point

This commentary examines three recent Nature studies demonstrating a conceptual shift in HIV vaccine design, demonstrating how germline-targeting HIV vaccines can progress beyond expanding rare broad neutralizing antibody (bnAb) precursors to deliberately guiding their affinity m...

Preferred service model and other factors associated with pre-exposure prophylaxis willingness among Indonesian men who have sex with men: analysis of PrEP APPEAL survey

BACKGROUND: Men who have sex with men (MSM) are disproportionately affected by HIV in Indonesia. To prevent transmission, there is a need to scale-up HIV prevention, especially pre-exposure prophylaxis (PrEP). This analysis aims to identify the preferred service model and factors...

Can Depression Polygenic Risk Score Predict Postinfective Fatigue Syndrome (PIFS) in the Dubbo Infection Outcomes Study (DIOS)?

Abstract Prospective cohorts show that a postinfective fatigue syndrome (PIFS) meeting criteria for chronic fatigue syndrome (CFS) develops in roughly 1 in 10 people after diverse acute infections, independent of the triggering pathogen. Whether constitutional liability to affect...

Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing

Epitranscriptomics has recently gained significant momentum due to technological advances and translational applications; however, studies on bacterial RNA modifications remain limited. Bacterial RNA is notoriously prone to degradation, and methodologies to investigate the epitra...