King University

Structure-Related Activity of 4-Alkylphenols in Hepatic Lipogenesis Regulated by Estrogen Receptor Agonism and Oxidative Stress

Abstract 4-Alkylphenols (APs), as typical endocrine-disrupting chemicals (EDCs) widely present in the environment and the human body, have been implicated in the disruption of lipid metabolism. However, the structure-activity relationships (SARs) and underlying mechanisms of thei...

Exposure to Size-Fractioned Ambient Particles Associated with Alterations in Gut Microbiome and Pro-Atherosclerotic Biomarkers in Young Adults

Abstract Background: Ambient fine and ultrafine particles are linked to the progression of atherosclerotic cardiovascular diseases, wherein gut microbiome may play a critical role. However, the underlying mechanisms and relevant metabolic pathways are not yet fully understood. Ob...

UAV-Satellite Integration Reveals Continuous Methane Emission Variability from Chinese Coal Mine Ventilation Shafts

Abstract Satellite quantification of coal mine methane lacks validation for continuously operating ventilation systems with high temporal variability. We integrate 75 unmanned aerial vehicle (UAV) flights (30 successful, 13 days) with 6.5 years of satellite observations at a Chin...

A Radical Spin Ladder

Abstract The spin ladder model is an important platform bridging one-dimensional and two-dimensional magnetic systems, with its physical properties modulated by geometric configuration. As such, the S = 1/2 two-leg antiferromagnetic spin ladder has attracted attention due to its...

State-Averaged Density Matrix Embedding Theory for Local Excitations

Abstract Density matrix embedding theory (DMET) provides an elegant framework in quantum chemistry to describe local properties of chemical systems, which allows a high-level method to solve an embedded subsystem constructed based on a low-level treatment of the whole system and...

Strategic breakthrough under ecological constraints: how biodiversity risk drives corporate mergers and acquisitions in China

Purpose This study examines how exposure to biodiversity risk shapes corporate merger and acquisition activities. Design/methodology/approach Using data on Chinese A-share firms listed on the Shanghai and Shenzhen stock exchanges from 2012 to 2023, this study employs a two-way fi...

Risk factor analysis and predictive model construction and evaluation of fractional uric acid excretion in Chinese inpatients with type 2 diabetes

Abstract Background and Aims: Fractional excretion of uric acid (FEUA) is currently acknowledged as a new risk factor of nephropathy. Precise measurement of FEUA requires withdraw medication during the washout time and 24h urine sample collecting, not always convenient, fostering...

Combining force and kinematic signals for human-computer interface: insights from cursor control by flexible pressure sensors

Cursor control becomes difficult in space-constrained environments, such as operating portable computers while wearing pressurised gloves. Flexible pressure sensorscan capture fingertip kinematic (centre of pressure, CoP) and force signals within confined spaces, offering a poten...

Coordination Engineering of Cobalt Single-Atom Catalysts for Periodate Activation with Regulated Reactive-Species Production toward Emerging Contaminants Degradation

Abstract Fenton-like reaction of heterogeneous periodate (PI) activation exhibits high efficiency for emerging contaminants degradation due to the production of iodine-centered radicals, and single-atom metal catalysts demonstrate high activity. However, precisely controlling the...

BeyondFreeze Concentration:Interfacial ProcessesShape Cr(VI) Reduction by Organic Acids in Frozen Systems

Abstract Ice-phase Cr(VI) reduction is commonly attributed to freeze concentration and proton enrichment, implicitly assuming solution-like reaction mechanisms. However, this study reveals that interfacial processes serve as a critical complement to freeze concentration and stron...

Prediction andControlling Factors of Macrolithotypesin Deep Coal Reservoirs

Abstract Deep coalbed methane (CBM) in the Ordos Basin is a critical resource for China’s unconventional gas supply. Accurate identification of coal macrolithotypes is essential for reservoir characterization and guiding efficient exploration and development. However, the deep co...

Isomer Effect of Double-Spiro Mechanophores in Polymer Mechanochemistry

Abstract Easy construction of rhodamine spiro rings and diversity of naphthalenediol enable various isomers of the naphthalene-fused double rhodamine structure and provide the possibility to study the structure–performance relationship of double-spiro mechanophores. Herein, we fo...

A Heterogeneous Metal–LigandBifunctional Catalystfor Chemoselective Hydrogenation of α,β-Unsaturated Aldehydes

Abstract The concept of metal–ligand bifunctional catalysts has been extensively explored in homogeneous catalysis, yet it has not been reported in conventional heterogeneous catalysis. Inspired by the outer-sphere hydrogenation mechanism in homogeneous metal–ligand bifunctional...

Assessment of masticatory muscle activity and mandibular border movement in skeletal class II malocclusion adolescents with mandibular retrognathia

<title>Abstract</title> Objective To investigate masticatory muscle activity and mandibular border movement in adolescents with skeletal class II malocclusion and mandibular retrognathia and explore the influence of mandibular retrognathia on masticatory system function. Methods...

Freeze–ThawCycles Greatly Affect the ConjugativeTransfer of Antibiotic-Resistant Genes: Effects of the Secretion ofExtracellular Polymeric Substances

Abstract Freeze–thaw (FT) cycle, a ubiquitous and important physical process in natural environments, may influence the horizontal gene transfer (HGT) process of antibiotic-resistant genes (ARGs), yet its impact and underlying mechanisms remain unclear. This study investigated th...

End-to-End Differentiable Learning of a Single Functionalfor DFT and Linear-Response TDDFT

Abstract Density functional theory (DFT) and linear-response time-dependent density functional theory (LR-TDDFT) rely on an exchange-correlation (xc) approximation that provides not only energy but also its functional derivatives, which enter the self-consistent potential and the...

A Tumor-Microenvironment-Responsive Chemically MaskedIL-2 Prodrug Potentiates PD-1 Checkpoint Blockade andElicits Robust Antitumor Efficacy

Abstract Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables...

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

ABSTRACT The emergence of drug‐resistant bacteria has brought a grand challenge to the treatment of oral ulcers (OUs). Peroxidase (POD) enzymes catalyze the conversion of hydrogen peroxide (H 2 O 2 ) into reactive oxygen species (ROS), offering a promising strategy for treating d...

Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology

Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently explored. Here, we show that mechanical fo...