King Saud bin Abdulaziz University for Health Sciences

Guideline Concordance and Documentation of Allopurinol Initiation Across Clinical Specialties: A Three-Year Retrospective Evaluation

Background/Objectives: To assess guideline concordance and indication documentation of new allopurinol prescriptions and whether these differed across clinical specialties. Methods: A retrospective study at a tertiary academic center in Riyadh, Saudi Arabia, included adults with...

Budget impact analysis of subcutaneous infliximab (CT-P13 SC) for treating autoimmune diseases in Jordan

Autoimmune diseases are increasingly prevalent, and their management in Jordan relies heavily on costly intravenous infliximab (IV IFX). Subcutaneous infliximab (IFX SC) may offer cost savings by reducing administration-related expenses. This study aims to investigate the financi...

From Infection to Oncology: AI-Assisted Drug Repurposing Uncovers Anti-Infective and Excipient-Class Compounds as PPAR-α-Linked Anticancer Agents

Drug repurposing offers an efficient strategy to identify novel anticancer agents from marketed compounds. We screened a library of ~1400 approved drugs using a PPARE–PPAR-α luciferase reporter assay to uncover modulators of lipid metabolism that induce cancer cell death without...

CT-based distribution of paranasal sinus involvement in sinusitis: A retrospective single-centre study

Background Sinusitis is among the most common inflammatory conditions of the paranasal sinuses, and computed tomography (CT) is the reference modality for demonstrating sinus involvement. The maxillary sinus is generally reported as the most frequently affected, but local data fr...

Depressive, Anxiety, and Stress Symptoms Among Respiratory Therapists in Two Tertiary Hospitals in Saudi Arabia: Differences According to Sociodemographic Characteristics

Background: Respiratory Therapists (RTs) work in high-stress environments, predisposing them to psychological distress. This study evaluated the proportion of depressive, anxiety, and stress symptoms and their differences across sociodemographic groups among RTs in two Saudi Arab...

Monitoring and control of antimicrobial resistance across the water continuum, from natural sources to engineered water systems

Chemical disinfection is heavily relied upon to arrest microbial regrowth in water systems, but its future must be reimagined. Growing evidence indicates that disinfectants themselves, along with persistent disinfectant residues and the formation of disinfection byproducts (DBPs)...

Multi-Chamber Dynamic Molecular Crystal Microcapsules for Payload Encapsulation and Controlled Release

Abstract Crystalline self-assembly offers a powerful route to ordered organic materials with well-defined structures and morphologies. Despite substantial advances in controlling crystal habit, organic single crystals with precisely engineered architectures, particularly those wi...

The Impact of Preexisting Cardiac Implantable Electronic Devices on the Safety of Transcatheter Tricuspid Valve Interventions: A Systematic Review and Meta-Analysis

Background: Tricuspid regurgitation (TR) increases mortality but remains undertreated due to high surgical risks. Transcatheter tricuspid valve interventions (TTVI) offer safer alternatives, improving functional status and quality of life. However, many candidates for TTVI have t...

Nurses’ experiences of occupational stress and its influence on their wellbeing and caring practices

Nursing is widely recognised as a profession associated with high levels of occupational stress. While quantitative studies have documented associations between occupational stress, wellbeing, and caring behaviours, less is known about how nurses themselves experience and describ...

Academic educators’ leadership styles and their associations with student engagement and critical thinking disposition among Saudi health sciences students: a mixed-methods study

Educator leadership behaviors are widely recognized as an important component of the classroom environment and may be associated with student engagement and critical thinking disposition. In health sciences education, these competencies are fundamental to clinical reasoning and e...

Artificial Intelligence-Enhanced Spirometry in Primary Healthcare: Opportunities for Early Detection of Small Airway Dysfunction

Spirometry underuse and persistent limitations in its technical quality and interpretation in primary healthcare (PHC) contribute to delayed and inaccurate diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Artificial intelligence (AI) has recently demonstrated...

N-Acetylcysteine Attenuates Amikacin-Induced Biochemical, Inflammatory, and Histopathological Alterations in Mice

Background: Amikacin is an effective aminoglycoside antibiotic, but its clinical use is limited by nephrotoxicity, hepatotoxicity, and neurotoxicity. N-acetylcysteine (NAC), a glutathione precursor and antioxidant, may help reduce these side effects. This study evaluated whether...

Prevalence of Delayed Healthcare Presentation and Associated Factors in Patients with Predominantly Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Background/Objectives: Traumatic brain injury (TBI) is a global burden and a leading cause of death and disability worldwide. Delayed healthcare presentation is significantly associated with poor outcomes. This systematic review and meta-analysis aim to estimate the prevalence of...

Assessing the osteoporosis care gap and clinical outcomes following fragility hip fractures in Saudi Arabia: implications for fracture liaison services

Abstract Background Osteoporotic hip fractures cause significant morbidity, mortality, and healthcare burden. Substantial gaps persist in osteoporosis diagnosis and secondary fracture prevention, particularly in Saudi Arabia. Aims To evaluate the osteoporosis care gap, mortality...

Changes in Glycemic Control and Lipid Profiles Following COVID-19 Infection in Adults with Type 2 Diabetes: A Retrospective Study in Saudi Arabia

Background: The clinical course and mortality risk of COVID-19 in patients with type 2 diabetes (T2D) remain elevated. Understanding its pathogenesis is essential for prognostic and therapeutic strategies. Viral infections can disrupt host glucose and lipid metabolism. This study...

Maternal satisfaction and childbirth experience in anaesthesia assisted and non anaesthesia assisted labour: a comparative study in Jeddah, Saudi Arabia

Abstract Background Maternal satisfaction during childbirth is a multidimensional concept influenced by pain management, perceived control, emotional support, and overall birth experience. Although neuraxial anaesthesia is effective in relieving labour pain, its impact on overall...

Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals

Background: COVID-19 vaccines have proven effective in reducing severe disease and mortality from SARS CoV-2 infection. The underlying molecular mechanisms and alterations in the human serum metabolome influencing the effectiveness and development of immunity remain unclear. Meth...

In vitro study and in silico reveal Teucrium Polium L. methanolic extract as an apoptosis inducer and a potential Bcl-2 inhibitor for breast cancer

Therapy of breast cancer (BC) overexpressing the pro-survival protein Bcl-2 remains a major clinical challenge. The discovery of natural anticancer drugs with potential as Bcl-2 inhibitors has generated increasing interest. The medicinal plant Teucrium polium L. (TPL) exhibits ph...

The clinical presentation and outcomes of dengue fever: a review of a tertiary care center in Saudi Arabia

Dengue fever (DF) is a viral infection spread by mosquitoes and is one of the most frequently reported infectious diseases in Saudi Arabia, particularly in Jeddah. Despite recurring outbreaks, recent data on the clinical characteristics, seasonal variation, and outcomes of affect...

Effectiveness of plasma atherogenic index as a predictor of cardiovascular risk in patients with metabolic syndrome and related cardiometabolic conditions: a systematic review.

Metabolic syndrome (MetS) and cardiovascular-kidney-metabolic syndrome represent escalating global health challenges characterized by complex lipid derangements. While traditional lipid panels are standard, the atherogenic index of plasma (AIP) has emerged as a potentially superi...