King Fahd Medical City

Depression and Anxiety Among Adolescents with Cancer: A Saudi Cross-Sectional Study

Background/Objectives: Adolescents undergoing treatment for cancer face both physical and psychological challenges, including depression and anxiety, yet local prevalence data remain limited in Saudi Arabia. The primary objective was to determine the prevalence of depressive and...

Impact of Smokeless Tobacco on Semen Quality: A Systematic Review and Meta‐Analysis

ABSTRACT Background Smokeless tobacco products are widely regarded as a safer alternative to smoking. However, a growing body of evidence points to harmful effects on male reproductive health. The aim of this systematic review and meta‐analysis was to assess the association betwe...

Development of clinical risk score for differentiating diabetic from non-diabetic kidney disease in a middle eastern cohort

Differentiating diabetic kidney disease (DKD) from non-diabetic kidney disease (NDKD) is challenging. Kidney biopsy remains the gold standard. The primary objective was to develop a clinically useful risk prediction model to distinguish DKD from NDKD. We retrospectively analyzed...

The Impact of Preexisting Cardiac Implantable Electronic Devices on the Safety of Transcatheter Tricuspid Valve Interventions: A Systematic Review and Meta-Analysis

Background: Tricuspid regurgitation (TR) increases mortality but remains undertreated due to high surgical risks. Transcatheter tricuspid valve interventions (TTVI) offer safer alternatives, improving functional status and quality of life. However, many candidates for TTVI have t...

Potentially inappropriate medication use and selected drug-related problems among older adults in Aseer Region, Saudi Arabia: a retrospective multicenter study

Older adults are at increased risk of medication-related safety concerns due to multimorbidity and polypharmacy. Potentially inappropriate medications (PIMs) and drug-related problems (DRPs) are important contributors to medication safety concerns in this population, yet hospital...

Assessing the osteoporosis care gap and clinical outcomes following fragility hip fractures in Saudi Arabia: implications for fracture liaison services

Abstract Background Osteoporotic hip fractures cause significant morbidity, mortality, and healthcare burden. Substantial gaps persist in osteoporosis diagnosis and secondary fracture prevention, particularly in Saudi Arabia. Aims To evaluate the osteoporosis care gap, mortality...

Blood Donation Deferral at a Tertiary Centre in Riyadh: Epidemiology, Sex-Specific Patterns, and Donor Retention Outcomes

Background: Blood donation deferral poses a significant challenge to transfusion services worldwide, threatening blood supply adequacy and donor retention. Population-specific data on deferral epidemiology and subsequent donor return behavior in Saudi Arabia remain limited. This...

Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals

Background: COVID-19 vaccines have proven effective in reducing severe disease and mortality from SARS CoV-2 infection. The underlying molecular mechanisms and alterations in the human serum metabolome influencing the effectiveness and development of immunity remain unclear. Meth...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Clinical characteristics and follow‑up of Saudi patients with adrenal incidentalomas: single‑center experience

Abstract Background Adrenal incidentalomas (AIs) are increasingly detected owing to the widespread use of cross-sectional imaging. However, real-world adherence to guideline-recommended evaluation remains variable. This study aimed to determine the prevalence, characteristics, an...

EUS-guided and US-guided percutaneous splenic biopsy: a systematic review and meta-analysis of separately pooled diagnostic and safety outcomes

Ultrasound (US)-guided percutaneous splenic biopsy has been widely used to evaluate focal or diffuse splenic lesions and has shown promising efficacy and safety. Endoscopic ultrasound (EUS)-guided biopsy has emerged as an alternative approach for tissue acquisition from splenic l...

Cerebral Microbleeds and Superficial Siderosis: Vascular Correlates and Cognition in a Memory Clinic

OBJECTIVE: Cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) are increasingly recognized in patients with cognitive impairment and are considered markers of cerebral small vessel disease and cerebral amyloid angiopathy (CAA). However, their associated variable...

Rheumatoid Factor‐Positive Polyarthritis as a Complication of Dabrafenib and Trametinib in a Child With BRAF V600E‐Mutated Pediatric Low‐Grade Glioma

The authors declare no conflicts of interest. Data sharing is not applicable to this article as no new datasets were generated or analyzed.