Key Laboratory of Guangdong Province

The mediating role of social determinants of health in the association between adverse childhood experiences and later-life cardiovascular disease

To investigate the longitudinal association between adverse childhood experiences (ACEs) and incident cardiovascular disease (CVD) in later life, and to examine whether the integrated construct of adult social determinants of health (SDH) mediates this association among middle-ag...

Development and application of a smartphone-based thermal contrast amplification reader for photothermal lateral flow immunoassays

The high cost and poor portability of external infrared thermal imagers have limited the widespread adoption of photothermal lateral flow immunoassays (PT-LFIAs) in on-site testing. To address this, we developed a smartphone-based handheld Thermal Contrast Amplification (TCA) Rea...

Lateral flow immunoassay for highly sensitive antibody detection of Clostridium perfringens ε toxin

ε-toxin, secreted by Clostridium perfringens , causes severe enterotoxemia in sheep and goats, resulting in substantial economic losses in the small ruminant industry. Monitoring ε-toxin-specific antibody levels is essential for early disease surveillance, vaccine-induced immunit...

When to stop? assessing the appropriate cycle of ovulation induction with timed intercourse in letrozole- or clomiphene citrate-sensitive polycystic ovary syndrome

To study how many cycles of ovulation induction with timed intercourse were appropriate for PCOS patients sensitive to letrozole or clomiphene citrate. A prospective study. A total of 655 women with PCOS were included who underwent 2633 cycles with ovulation induction followed by...

D-allose reprogrammes the mitophagy–mtDNA–cGAS–STING–ADM2 axis to restore nucleus pulposus cell homeostasis in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is driven by progressive loss of nucleus pulposus cell (NPC) homeostasis, yet the stress-responsive mechanisms governing this process remain incompletely defined. Here, we identify a mitochondrial stress-innate immune signalling axis in whi...

Perioperative prediction of ideal postoperative recovery after kidney transplantation: a multicenter retrospective cohort study

Kidney transplantation is the preferred treatment for end-stage renal disease, but early postoperative outcomes remain heterogeneous. Textbook outcome (TO), a composite measure of an ideal postoperative recovery trajectory, has emerged as a meaningful indicator of surgical qualit...

Structural and diffusion MRI markers of the choroid plexus and perivascular regions are associated with Alzheimer’s disease pathology and cognition

Abstract Background Choroid plexus (ChP) morphology and periventricular diffusion alterations have been implicated in Alzheimer’s disease (AD). However, whether ChP volume and the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provide complementar...

Investigation of CO2-to-methanol hydrogenation performance over Cu-ZnO/ZrO2 catalysts by tuning ZrO2 crystalline phases

Cu-ZnO/ZrO 2 catalysts are promising for CO 2 hydrogenation to methanol, yet the role of ZrO 2 phase composition remains unclear. Here, monoclinic and tetragonal ZrO 2 were separately prepared and combined to construct catalysts with systematically varied m/t-ZrO 2 compositions....

Breaking Barriers Toward Practicality: Critical Materials and Strategies for High‐Energy‐Density Aqueous Zinc‐Ion Batteries

ABSTRACT Driven by the demands of grid‐scale energy storage and the electrification of transport, achieving superior energy density is pivotal to establishing a more sustainable and economically resilient battery ecosystem. However, aqueous zinc‐ion batteries (ZIBs), despite thei...

Admission low-density lipoprotein cholesterol and early haematoma expansion after spontaneous intracerebral haemorrhage

Background The association between low-density lipoprotein cholesterol (LDL-C) and haematoma expansion (HE) after spontaneous intracerebral haemorrhage (ICH) remains uncertain. This study evaluated whether admission LDL-C was independently associated with early HE and whether it...

Nitric oxide–regulated temporally staged milk exosome hydrogel for the treatment of skin photoaging

Ultraviolet (UV)–induced skin photodamage can lead to sunburn, photoaging, and, in severe cases, precancerous lesions or malignant skin tumors. Cutaneous responses to UV injury exhibit pronounced circadian rhythmicity; however, current strategies focusing solely on physical UV sh...

Integrated Bulk and Single-Nucleus Transcriptomics Characterizes the Developmental and Regional Specialization of Chicken Abdominal Fat-Associated Tissue

Excessive abdominal fat deposition reduces feed efficiency and edible carcass yield in chickens, yet its developmental and regional specialization remains poorly understood. We generated 93 bulk RNA sequencing (RNA-seq) libraries from 15 fat-associated anatomical regions at embry...

Mitochondrial genetic diversity, population structure and late Pleistocene demographic expansion of Evynnis cardinalis in the northern South China Sea

Understanding how historical processes and contemporary oceanography shape population connectivity and demographic dynamics is essential for effective management of coastal marine fishes. In this study, we investigated the genetic diversity, population structure, and demographic...

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

ABSTRACT Despite architectural advances, current nerve guidance conduits inadequately replicate the mechanoactive microenvironment required for functional neural regeneration. While membrane tension is increasingly recognized as an important biomechanical regulator of axonal exte...

Cytological and Transcriptomic Profiling Reveals the Developmental Basis of Stem Diameter Variation in Luffa

Stem diameter is an important agronomic trait determining plant architecture, lodging resistance and yield formation, yet its cytological and molecular mechanisms in the major cucurbit crop Luffa remain largely unclear. Herein, two Luffa inbred lines, S1174 (Luffa acutangula, thi...

Comparative study on the effects of 2D and 3D cell culture on the functions of stem cells from the apical papilla

Dental-derived stem cells (DSCs), especially stem cells from the apical papilla (SCAP), are vital for regenerative medicine. Three-dimensional (3D) cell culture is superior to two-dimensional (2D) culture in mimicking in vivo environments. A dynamic 3D culture system consisting o...

Effects of dietary protein levels on ovarian development in broodstock of Scatophagus argus

Protein is a critical nutrient during fish reproduction, and its intake level directly affects gonadal development and reproductive performance of broodstock. This study evaluated the effects of three dietary crude protein levels-31.21% (Group A), 38.52% (Group B), and 45.80% (Gr...

Interpretable machine learning model for predicting the ICU readmission of patients after coronary intervention

To develop and validate an interpretable machine learning (ML) model integrated with inflammatory indicators for predicting ICU readmission in patients after coronary intervention (PCI/CABG). We used retrospective data from MIMIC-IV (training, 2196 patients) and MIMIC-III (extern...

Tracking Variability in Atmospheric, Oceanic, and Riverine Inputs to the Iberian Margin Over the Last 250 kyr

Abstract The Iberian Margin provides an exceptional archive of climate variability due to its high sedimentation rates. However, uncertainties persist regarding the provenance of terrigenous detrital sediments on the Iberian Margin, and the climate‐driven changes in their source...

Benzo[a]pyrene-induced METTL3 overexpression accelerates renal cell carcinoma progression via m6A modification of LTB4R mRNA and enhanced Treg infiltration

Benzo[ a ]pyrene (BaP) is a widespread environmental pollutant and a representative polycyclic aromatic hydrocarbon with well-established carcinogenic properties. However, the molecular mechanisms through which BaP promotes renal cell carcinoma (RCC) progression, particularly tho...