Key Laboratory of Guangdong Province

Benzo[a]pyrene-induced METTL3 overexpression accelerates renal cell carcinoma progression via m6A modification of LTB4R mRNA and enhanced Treg infiltration

Benzo[ a ]pyrene (BaP) is a widespread environmental pollutant and a representative polycyclic aromatic hydrocarbon with well-established carcinogenic properties. However, the molecular mechanisms through which BaP promotes renal cell carcinoma (RCC) progression, particularly tho...

Motor imagery enhances swallowing motor cortex excitability and activates sensorimotor regions: a TMS and fNIRS study

Action observation (AO) and motor imagery (MI) represent promising, non-invasive strategies for promoting neuroplasticity in motor rehabilitation by engaging the shared neural substrates of actual movement. However, their translation to swallowing rehabilitation, particularly for...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

CD36-mediated lipid-accumulation in reactive microglia contributes to retinal degeneration via the NLRP3-IL-1β pathway in mice

Microglia are central regulators of retinal immune homeostasis, yet their pathogenic states in retinal degeneration remain less well understood. Here we identified a distinct subset of lipid-accumulated reactive microglia (aLARM), using scRNA sequencing and spatial transcriptomic...

Genome-wide association study reveals putative genetic determinants of longitudinal immune responses to avian influenza and Newcastle disease in chickens

Abstract Background Avian Influenza virus (AIV) and Newcastle disease virus (NDV) are highly contagious immunosuppressive pathogens that cause high mortality rates and economic losses in the global poultry industry. Although vaccination to enhance the host antibody response remai...

Porous biochar confined Ru nanocatalysts: Dual defense mechanism enables ultrahigh SO2 tolerance for methane dry reforming

Methane dry reforming (DRM) can convert greenhouse gases into valuable syngas, while sulfur dioxide (SO 2 ) in feed gas easily poisons Ru-based catalysts. Herein, 1Ru/C, 1Ru/MgO and 1Ru/TiO 2 catalysts were synthesized and evaluated for DRM in the presence of SO 2 . Characterizat...

Comparative Immunogenicity of Inactivated H7N9 Avian Influenza Vaccines with Different Internal Gene Backbones

H7N9 avian influenza virus (AIV) poses a persistent threat to poultry and public health. Despite widespread vaccination in China, rapid antigenic drift and reassortment necessitate frequent updates of vaccine strains. Phylogenetic analysis of isolates from Chinese provinces (from...

Cardiac MR Characterization of Infarct‐Related and Remote Myocardial Injury in Multivessel Disease After Acute Myocardial Infarction

BACKGROUND: Patients with multivessel disease (MVD) after acute myocardial infarction (AMI) have worse outcomes than those with single-vessel disease (SVD), but whether MVD is associated with diffuse myocardial injury beyond the infarct zone (IZ) remains unclear. PURPOSE: To char...

IL10RB-AS1 promotes pro-caspase-1-dependent pyroptosis via regulating the oligomerization and nucleation of CARD8 C-terminal domain to suppress acute myeloid leukemia

Abstract CARD8 (caspase activation and recruitment domain-containing 8) senses intracellular danger signals, leading to inflammasome formation and pyroptosis. Recently studies have shown that CARD8 was highly expressed in hematopoietic cells, however, the mechanism by which the r...