Kermanshah University of Medical Sciences

Association between mode of delivery and postpartum depression among primiparous women: a prospective follow-up study

Mode of delivery has been proposed as a potential risk factor for postpartum depression (PPD); however, findings from previous studies have been inconsistent. This study investigated the association between mode of delivery and PPD among primiparous women. This prospective follow...

Efficacy of Topical 5% Doxepin Cream Compared with Diclofenac Gel and Placebo for Knee Osteoarthritis: A Randomized Double-Blind Clinical Trial

Abstract Background and purpose Osteoarthritis is the most common type of arthritis, and knee osteoarthritis is one of the most important forms, causing symptoms such as knee pain and stiffness, followed by reduced physical performance and a decreased quality of life. Among compl...

A homozygous missense variant in the GUCY2D gene associated with Leber congenital amaurosis in an Iranian family: molecular docking insights and genetic analysis

Leber congenital amaurosis encompasses a genetically heterogeneous spectrum of inherited retinal disorders, typically following an autosomal recessive inheritance pattern, with onset in infancy or early childhood. Several genes have been associated with LCA, including GUCY2D , wh...

A Comprehensive Review on Furcellaran‐Based Food Packaging: Applications, Developments and Horizons

ABSTRACT Growing concerns regarding the uncontrolled proliferation of plastic materials, which pose significant environmental challenges, have prompted researchers to seek innovative, eco‐friendly alternatives to conventional petroleum‐based packaging. Among various biological so...

Blood zinc and copper levels in children with autism spectrum disorder: a systematic review and meta-analysis

Abstract Background and aims Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental condition shaped by genetic, environmental, and biochemical influences. Among these, trace elements such as zinc (Zn) and copper (Cu) have attracted considerable interest due to their...

Systematic review and meta-analysis of modifiable risk factors affecting organ-space surgical site infections and their impact on long-term transplant outcomes following liver transplantation

Liver transplantation is one of the most successful achievements in modern surgery, but surgical site infections, particularly organ-space infections, remain a major challenge. These infections include intra-abdominal abscesses, biliary infections, and peritonitis, and can have l...

Advancing nanomaterials for treatment of eye diseases: a review

Ocular diseases involving both the anterior and posterior segments-such as dry eye disease, keratitis, glaucoma, cataracts, diabetic retinopathy, retinal vein occlusion, and ocular tumors-remain major contributors to global visual impairment. Conventional topical and systemic the...

Bony labyrinth taxonomic identification and long-term evolution of livestock in the Southwest and Central Asia

Abstract Southwest and Central Asia were pivotal regions for the domestication and dispersal of domestic herbivores. Here we investigate long-term variation in bony labyrinth morphology of domestic bovids (sheep, goats and cattle) across the last 10 000 years. We focused on the o...

Immersive virtual reality for preoperative anxiety management in patients undergoing elective lumbar laminectomy: a randomized controlled trial

This study aimed to investigate the effectiveness of immersive virtual reality (VR)-based preoperative education compared with attention-matched routine in-person education in reducing preoperative anxiety and physiological stress responses among adult patients undergoing electiv...

Identification of bacterial communities, structure, and dynamics during cattle and poultry manure composting

Biochar-assisted composting has emerged as a promising strategy for improving the stabilization of animal manure and modifying composting conditions. This study evaluated the physicochemical performance and temporal bacterial succession during in vessel composting of cattle and p...

Contextual and perceptual challenges in cardiopulmonary resuscitation: a qualitative study

Cardiopulmonary resuscitation (CPR) is life‑saving, yet its effectiveness is often compromised by challenges beyond clinical guidelines. In Iran, survival rates following cardiac arrest remain low, underscoring the need to identify barriers to effective resuscitation. This study...

Venom-derived and natural analgesic peptides: From venomics-based discovery to computational design and therapeutic development

Pain is a complex physiological process and an important clinical issue due to thelimitations of the existing analgesics. Side effects, tolerance anddependence, and limited efficacy for the treatment of chronic pain are common complications of classic drugs, e.g., opioids and non...

Possible role of bacterial infection in embryo implantation failure

Embryo implantation is a critical and complex process that requires coordination between the embryo and the receptive endometrium for its success. However, a multitude of factors have the potential to contribute to implantation failure. Among these factors, bacterial infections i...

Clinical development of human vaccine candidates against Shigella flexneri: a systematic review of clinical trials

Shigella flexneri remains a leading cause of shigellosis, particularly in low- and middle-income countries, where it contributes substantially to childhood morbidity, mortality, and the growing burden of antimicrobial resistance. Despite decades of vaccine research, no licensed v...

Protodioscin mitigates cyclophosphamide-induced renal toxicity in HEK-293 cells by regulating endoplasmic reticulum stress, antioxidant defense, and apoptotic pathways

Cyclophosphamide (CTX) is a widely used chemotherapeutic agent with well-established efficacy; however, its clinical use is limited by dose-dependent adverse effects, particularly nephrotoxicity. Protodioscin (Prot), a bioactive saponin derived from plants of the Dioscoreaceae fa...

Nanoarchitectonics of phenolic acid-functionalized gold nanoparticles: A bioinspired nanoplatform for erythrocyte membrane and protein protection, bacterial and cancerous cellular toxicity

Abstract Ferulic acid-trans form (TFA) was applied for the biosynthesis of gold nanoarchitectonics (TFA-GNPs) as a reducing and stabilizing agent under optimal conditions. The most favorable conditions for this synthesis included a pH of 7, a reaction duration of 4 h, and a tempe...

Typology of learning styles in medical students: a systematic review of 33 countries

Understanding students' learning styles is crucial for guiding the teaching–learning process according to their individual needs and preferences, and for creating effective pedagogical situations. Therefore, this systematic review aimed to identify learning styles in medical stud...

Qualitative exploration of challenges in cardiopulmonary resuscitation within pediatric intensive care units (PICU)

Cardiopulmonary resuscitation (CPR) in the Pediatric Intensive Care Unit (PICU) is a vital, sensitive, and complex process that has a direct impact on patient survival and prognosis. Any disruption during the resuscitation process may lead to irreversible consequences. However, v...

Design and validation of the love in nursing instrument

Abstract Existing instruments designed to measure the construct of love exhibit various limitations or fail to specifically address love within the nursing context. Consequently, there is a distinct lack of a unified, domain-specific tool to evaluate love in the nursing professio...

Association between preoperative hypoalbuminemia and postoperative complications in spinal fusion surgery: an approach- and spinal level-stratified meta-analysis

While hypoalbuminemia is recognized as a risk factor for adverse postoperative outcomes in various surgeries, its specific impact on spinal fusion outcomes has not been systematically synthesized. This meta-analysis aimed to evaluate the association between preoperative hypoalbum...