Kasturba Medical College, Manipal

Identification of kinematic motifs in crouch gait of children with cerebral palsy

Abstract Crouch gait is among the most disabling gait deviations in cerebral palsy (CP). Powered exoskeletons can supply the extensor thrust orthoses cannot, but their control depends on repeatable kinematic patterns, and crouch gait is perceived as irregular. Five children with...

Effectiveness of conservative interventions on pain and disability in degenerative cervical spine disease: a systematic review and meta-analysis of randomized controlled trials

Abstract Background Degenerative cervical spine disease (DCSD) is a major cause of neck pain and disability worldwide. Although conservative interventions are widely used as first-line management, their comparative effectiveness remains unclear. This systematic review and meta-an...

Orbiting towards myopathy: new paradigms of muscle atrophy in spaceflight

Abstract Protracted exposure to microgravity during spaceflight imposes stress on the human body which disrupts physiological homeostasis. Skeletal muscles are among the most severely affected, and they are characterized by rapid muscle atrophy. Although basal autophagy maintains...

Efficacy and Safety of Non-steroidal Versus Steroidal Immunosuppressants in Vitiligo Treatment: A Systematic Review and Meta-analysis

Vitiligo is an acquired chronic autoimmune depigmentation disorder, and mainstream treatment options for vitiligo are non-steroidal immunosuppressants/immunomodulators (NSIs) and steroidal immunosuppressants (SIs). However, there are variations in the efficacy and safety of NSIs...

Same hospital, same price, different protection: out-of-pocket expenditure for emergency trauma under public insurance, private insurance and self-payment in India

Background Out-of-pocket expenditure (OOPE) finances 43.4% of total health expenditure in India, and emergency trauma—unforeseeable, unpostponable and costly—is among the sharpest tests of whether a health-financing mechanism protects households from catastrophic spending. Insure...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Strategic Innovation in the Bakery Industry Through Underutilized Bioresources: A Narrative Review of Nutritional Enhancement, Circular Economy Approaches, Consumer Acceptance, and Industry 4.0 Technologies

The bakery industry is undergoing paradigm shifts due to increased customer demand for healthy foods, sustainable manufacturing techniques and innovations. At the same time, growing concerns about food waste, environmental harm and the depletion of natural resources are driving i...

Burden assessment tools in epilepsy caregiving: A scoping review

Background Informal caregivers of people with epilepsy (PWE) experience a substantial burden because of the chronic nature and unpredictability of seizures. Although several caregiver burden assessment tools are available to quantify this burden, little is known about which of th...

Delivery room skin-to-skin contact for preterm neonates: a systematic review and meta-analysis

Abstract Background Immediate skin-to-skin contact (SSC) is the biological norm for newborns; however, preterm infants are routinely separated from their mothers at birth because of fears of thermal and clinical instability. This practice prioritizes technical stabilization and p...

Epigenetic modulators of melanogenesis: the role of environment, lifestyle, and stress

Abstract Melanogenesis is the process through which a pigment called melanin is produced by melanocytes in melanosomes. Increased or decreased production of melanin through melanogenesis can lead to pigmentation diseases, namely, hyperpigmentation and hypopigmentation. Melanogene...

Antifungal pulse therapy for onychomycosis: a narrative review

PURPOSE: Onychomycosis is a common chronic fungal infection of the nail unit that may be associated with significant functional impairment and impaired quality of life. Systemic antifungal drugs remain the cornerstone of treatment for moderate-to-severe disease, with continuous o...

Hybrid endoscopic submucosal dissection enhances efficiency with comparable curative outcomes: a Bayesian meta-analysis, systematic review, and Monte Carlo simulation of randomized controlled trials

Background/Aims: Gastrointestinal (GI) cancers accounted for 3.24 million deaths worldwide in 2022. Endoscopic submucosal dissection (ESD) enables en bloc resection of early neoplasms but is time-intensive and technically challenging. Hybrid ESD (H-ESD), which combines dissection...

Health-facility readiness and provider-perceived barriers and facilitators to animal-bite management in Mangalore, India: a mixed-methods study

Abstract Rabies remains a global fatal disease yet fully preventable zoonotic disease, with India accounting for a substantial share of global deaths. Timely and full post exposure prophylaxis following animal bites is crucial, but its effective delivery depends mainly on the rea...

Influence of stem geometry and material combinations on the biomechanical and tribological performance of hip implants using finite element analysis

Abstract This study investigate the biomechanical behavior and wear characteristics of different hip implant geometries and materials using finite element analysis (FEA). Total hip arthroplasty (THA) success critically depends on design, which influences stress distribution, dura...

Development of a penalized clinical risk score for oral squamous cell carcinoma

Abstract Introduction Prompt diagnosis of Oral Squamous Cell Carcinoma (OSCC) is key to favorable outcomes, but in low- and middle-income settings, constrained access to timely histopathology and imaging often leads to delayed detection. The NDB UFES dataset provides demographic,...

Feasibility and preliminary effects of a structured home-based pulmonary rehabilitation on functional exercise capacity in individuals with bronchiectasis: a pilot randomised controlled trial

Abstract Background Pulmonary rehabilitation is widely recognized as an effective intervention for chronic respiratory diseases; however, access to supervised programmes remains limited. Evidence on home-based pulmonary rehabilitation (H-PR) in individuals with bronchiectasis is...

Recognizing and Addressing Fertility Issues among Childhood Cancer Patients and Survivors in India – A Multi Stakeholder Position Statement and Call to Action

Abstract Survival rates in childhood and adolescent cancers have improved substantially over the past decades, leading to a growing population of long-term survivors. In India, an estimated 76,000 children and adolescents are diagnosed with cancer annually, and approximately one-...

Knowledge and attitude towards breast and cervical cancer screening among women caregivers of cancer patients: a cross-sectional study from a tertiary cancer centre in India

Abstract Purpose Female informal caregivers, who provide critical support to cancer patients, may face substantial caregiver burden that may adversely affect their participation in preventive healthcare. We aimed to evaluate their knowledge and attitudes toward breast and cervica...

Annasaheb Latthe: The Evolution of a social reformer, Educationalist and Public Leader

This study examines the evolution of Annasaheb Latthe as a social reformer, educationist and public leader. It showcases his journey through his contributions to social reform, education and politics. His relation with Chhatrapati Shahu Maharaj influenced his reformist social ang...

Annasaheb Latthe: The Evolution of a social reformer, Educationalist and Public Leader

This study examines the evolution of Annasaheb Latthe as a social reformer, educationist and public leader. It showcases his journey through his contributions to social reform, education and politics. His relation with Chhatrapati Shahu Maharaj influenced his reformist social ang...