Kasturba Medical College, Manipal

Comparison of Ultrasound versus Combined Peripheral Nerve Stimulator Plus Ultrasound-guided Supraclavicular Blocks of Brachial Plexus for Upper Limb Surgeries

Abstract Background: Ultrasound (USG)-guided supraclavicular blocks are an asset in the realm of regional anaesthesia. Newer approaches, such as USG plus peripheral nerve stimulator (PNS), have often been indicated for better outcomes. Aim: The aim of the study was to compare USG...

Urinary metabolomic signatures associated with left ventricular hypertrophy in chronic kidney disease: an exploratory gas chromatography-mass spectrometry study

Abstract Although left ventricular hypertrophy (LVH) is common in people with chronic kidney disease (CKD); its mechanisms are not well understood. Metabolomic profiling may reveal novel mechanistic pathways linked to cardiac remodelling in CKD patients. In this single-centre cro...

Clinicopathological characteristics, diagnostic challenges, and systemic implications of metastatic tumors to the eyelid: a systematic review

Abstract Background Metastatic tumors to the eyelid are rare but clinically significant, often indicating advanced systemic malignancy or presenting as the first sign of an occult primary. Histopathology is the diagnostic cornerstone, yet the spectrum of clinicopathological patte...

Fetal atrial strain: a scoping review of physiology, methods, and clinical applications

Abstract Background The evaluation of fetal cardiac function is moving towards the angle-independent myocardial deformation techniques, including the atrial strain obtained with speckle-tracking echocardiography. Angle-independent myocardial deformation techniques are gaining inc...

Medullary Carcinoma of the Colon: A Case Report

Colorectal cancer (CRC) is a significant global health burden. Medullary carcinoma (MC) of the colon is a rare histological subtype, accounting for less than 3% of CRCs and often associated with hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized histologically...

Bulk and single-cell multiomics insights into theca cell and granulosa cell dysfunction in polyendocrine metabolic ovarian syndrome

Abstract Polyendocrine metabolic ovarian syndrome (PMOS) is a heterogeneous disorder marked by a variety of clinical, hormonal, and metabolic disorders of an endocrine nature, affecting women of reproductive age and causing anovulatory infertility, metabolic dysfunction and hormo...

Successful caesarean section under spinal anaesthesia in a pregnant woman with guillain–barré syndrome: a case report from a resource-limited setting

Guillain-Barre syndrome (GBS) is a rare but serious neurological condition due to autonomic instability, decreased respiratory function, and unpredictable medication responses, which can make pregnancy difficult and provide considerable anaesthetic issues. We report a case of a 2...

Ears for examinations: a multicentre quasi-experimental evaluation of AI-generated revision podcasts on learning outcomes and retention among medical students

Abstract Background Medical curricula overload necessitates efficient, self-directed learning strategies that can utilize ‘dead time’ for study. AI-generated audio offers a scalable resource for this purpose, yet evidence regarding its efficacy in low-resource settings is limited...

Association of small nerve fiber dysfunction on pain characteristics in type 2 diabetes mellitus individuals with chronic low back pain

Abstract Type 2 diabetes mellitus (T2DM) is associated with small nerve fiber (SNF) dysfunction. Quantitative assessment of thermal perception thresholds is a validated method for evaluating SNF dysfunction. Pain characteristics such as numbness and pain irritability are commonly...

Acute respiratory distress syndrome in scrub typhus: a systematic review and meta-analysis

PURPOSE: Acute respiratory distress syndrome (ARDS) is an important complication of scrub typhus and is associated with substantial mortality. The primary objective of this systematic review and meta-analysis was to estimate the proportion of hospitalised patients with microbiolo...