Karpagam Academy of Higher Education

Immunoinformatics-based design and in silico evaluation of a multi-epitope vaccine candidate against Naegleria fowleri

Primary amoebic meningoencephalitis (PAM) is caused by Naegleria fowleri , a free-living amoeba. It is a fatal infection with more than 95% mortality rate. Even though several combinations of antimicrobial agents were used to treat the condition, the overall survival remains poor...

Unlocking catalytically active sites in FeMnS/MXene@Ni(OH)2 arrays via heterojunction strategy for highly efficient overall water splitting

Developing efficient and earth-abundant bifunctional electrocatalysts for water electrolysis remains a critical challenge due to sluggish reaction kinetics and limited structural durability. Herein, a FeMnS/Ti 3 C 2 T x @Ni(OH) 2 (NFMM) heterostructure is fabricated through the s...

Comprehensive review of substrate selection process conditions risk and industrial feasibility for sustainable lactic acid production

One important framework chemical is lactic acid (2-hydroxypropionic acid) for food, medicine, and bioplastics. To meet the increasing demand for lactic acid, its procedures must be optimized for higher yields, improved efficiency, and sustainable development. Traditional fermenta...

Data-driven robust design for industrial cylindrical plunge grinding of piston rings: Requirements for reliable digital-twin development under production noise

Cylindrical plunge grinding of piston rings is a precision finishing operation, and its dimensional accuracy governs engine sealing and emission compliance. It is widely assumed that such accuracy can be controlled through fixed machine settings; this study tests this assumption...

Effect of Maranta arundinacea L. ethanolic extract against chronic inflammation in CFA-induced arthritis rats

OBJECTIVES: L. (EEMA) on chronic inflammation in a Complete Freund's adjuvant (CFA) -induced arthritic animal model. METHODS: anti-arthritic activity of EEMA was assessed using the proteinase-inhibitory assay. About 0.05 mL of Complete Freund's adjuvant was injected intraplanar i...

Enhanced strength and durability with sustainable geopolymer concrete with copper slag as fine aggregate replacement

The production of Ordinary Portland Cement (OPC) contributes significantly to CO2 emissions globally, making the quest for sustainable building materials imperative. The research focuses on creating geopolymer concrete with jute fiber reinforcing, copper slag as a partial substit...

Enhancing Video Captioning with Global Transformer and Beetle Optimization Techniques

Although video captioning has advanced significantly, it is still difficult to produce precise, context-aware, and coherent captions for a variety of complex and varied video content. Traditional approaches frequently have problems detecting and characterizing dynamic scenes, eff...

Anterior Cervical Approaches for 2-Level Radiculopathy

Study Design: Anonymous, survey-based study. Objective: The primary objective of this study is to understand and assess the factors influencing the choice of cervical fusion, disc arthroplasty, and hybrid procedures for radiculopathy in the setting of 2-level cervical degenerativ...

BioPhysio-guided hybrid transformer-UNet for early Alzheimer's disease staging and longitudinal progression prediction using multimodal ADNI data

Detection of Alzheimer’s disease (AD) has proven difficult; further complicating the issue is determining the progression of the condition, as there are very slight structural changes and considerable variability among imaging datasets collected from each patient. Current approac...

Eco-responsive CeCo-MOF/g-C3N4 heterointerfaces for electrochemical detection of nilutamide in aquatic systems

The widespread occurrence of pharmaceutical contaminants in aquatic environments necessitates the development of sensitive and sustainable sensing platforms for environmental monitoring. In this work, a bimetallic cerium‑cobalt metal-organic framework (CeCo-MOF) integrated with t...

Fusion Partner and ER-Retention Signal Are Associated with Distinct Host Proteomic and Metabolic Responses During Interleukin-15 Production in Nicotiana benthamiana

Plant molecular farming has emerged as a promising platform to produce recombinant biopharmaceuticals. The expression of foreign proteins changes the host proteome and metabolome, and these changes might have an effect on the accumulation of recombinant proteins. In this study, w...

Hydrothermal preparation of Nickel oxide nanoparticles for photocatalytic removal of Congo red and antibacterial applications

Nickel oxide nanoparticles were successfully synthesized using a simple hydrothermal method and systematically characterized for photocatalytic and antibacterial applications. The UV–visible absorption spectrum revealed strong absorption in the ultraviolet region, and the optical...

Thermophysical properties, combustion, performance, and emission analysis of ZnO, TiO₂, and GNP-enhanced WCOME–diesel–DGM triple fuel blends in a CRDI diesel engine

The continuous utilization of non-renewable/conventional fuels for different fields of applications creates intense demand, increasing costs, and hazardous exhaust gases, which cause depletion of these products from the Earth’s source. This scenario urges researchers to find alte...

Blue carbon ecosystems under pollution stress: Impacts and integrated carbon‐pollution monitoring

Abstract Coastal blue carbon ecosystems, including mangroves, seagrass meadows, and salt marshes, are globally important carbon sinks because they store organic carbon in vegetation biomass and waterlogged sediments over long timescales. However, nutrient enrichment, heavy metals...

Efficient Resource Management in 6G for Sustainable Spectrum Allocation Using Dual‐Channel Temporal Convolutional Frequency‐Separated Attention Network with Generation Rights Trading Blockchain

ABSTRACT The need for effective spectrum allocation to guarantee highly reliable, minimal‐latency, and sustainable connections has increased due to the exponential expansion of wireless communications and the introduction of 6G technologies. In order to cope with these challenges...

Design and development of sustainable sports shoes using recycled materials in compliance with testing standards

The growing environmental impact of conventional athletic footwear manufacturing necessitates sustainable design approaches that reduce carbon emissions while maintaining functional performance. This study presents the design, development and evaluation of a sustainable sports sh...

MULTI-FUSE: Multimodal Late Fusion Framework for Hate Speech Detection in Videos

Abstract Addressing cyberbullying and fostering more welcoming online communities depend on the detection of hateful content. However, because it requires examin-ing a number of interrelated components, including spoken words, visual imagery, and text within those visuals, detect...

MULTI-FUSE: Multimodal Late Fusion Framework for Hate Speech Detection in Videos

Abstract Addressing cyberbullying and fostering more welcoming online communities depend on the detection of hateful content. However, because it requires examin-ing a number of interrelated components, including spoken words, visual imagery, and text within those visuals, detect...

Enhanced removal of profenofos from water/wastewater via photocatalytic adsorption using biosynthesized TiO₂ nanoparticles: a comparative study with Fenton process

This study compared the efficacy of combined adsorption–photocatalytic process using biosynthesized TiO 2 nanoparticles with the Fenton process in removing profenofos. Characterization techniques such as BET, XRD, and SEM were employed to characterize the biosynthesized nanoparti...

Combined photovoltaic and thermal enhancements of solar photovoltaic system using SiO2 and Al2O3 nanoparticle-enhanced paraffin wax phase change material

This study addresses the reduction in electrical efficiency and power output caused by elevated operating temperatures in Solar Photovoltaic Thermal (SPVT) panels by implementing an effective cooling approach to enhance energy yield and overall system performance. The study exper...