Kangbuk Samsung Hospital

Clinical Outcomes of Switching from Prostaglandin Analogs to Omidenepag Isopropyl in Primary Open-Angle Glaucoma and Glaucoma Suspect Patients with Prostaglandin-Associated Periorbitopathy: A Prospective, Multicenter Study

Background/Objectives: Prostaglandin-associated periorbitopathy (PAP) is a common treatment-related burden of prostaglandin analog (PGA) therapy that may compromise long-term glaucoma management. This study evaluated improvement in PAP and changes in intraocular pressure (IOP) af...

Atropine-Associated Central Anticholinergic Syndrome during Carotid Artery Stenting: A Case Report

Acute neurobehavioral deterioration during carotid artery stenting (CAS) requires prompt evaluation for serious neurological complications. We report a patient in their 70s who developed profound hyperactive delirium approximately 15 minutes after receiving prophylactic intraveno...

Layer-Specific Associations of Axial Length With Retinal and Choroidal Thickness: A Nationally Representative Population-Based Study

Purpose: To characterize layer-specific, potentially non-linear associations between axial length (AL) and macular ganglion cell–inner plexiform layer (GCIPL), peripapillary retinal nerve fiber layer (RNFL), outer-retinal, and subfoveal choroidal thickness (SFCT) in a nationally...

Diagnostic performance of the Korean oral frailty screening questionnaire and diagnostic criteria for physical frailty, sarcopenia, and malnutrition: a pilot study

The association between declining oral health and function and the development of frailty, disability, and mortality has been well documented. This study aimed to evaluate the diagnostic performance of the Korean oral frailty diagnostic criteria and screening questionnaire for id...

Early Discontinuation of Opioid-Based Intravenous Patient-Controlled Analgesia After Single-Port Adnexal Laparoscopy: Incidence, Reasons, and Postoperative Outcomes

Background/Objectives: Opioid-based intravenous patient-controlled analgesia (IV-PCA) provides postoperative analgesia but can cause adverse effects that lead to early discontinuation. In relatively limited procedures such as single-port access (SPA) adnexal laparoscopy, the bala...

Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial

PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...

Axial Length–Adjusted Normative Reference Values for Retinal Layer Thickness in a Population-Based OCT Study

Purpose: To establish axial length-adjusted normative reference values for retinal layer thickness using population-based optical coherence tomography (OCT) data and evaluate their clinical implications in highly myopic eyes. Methods: This cross-sectional study used Korea Nationa...

Apolipoprotein B relative to LDL cholesterol and diabetes in relation to brachial-ankle pulse wave velocity progression

Factors associated with longitudinal progression of brachial-ankle pulse wave velocity (baPWV) are less well established than correlates of single-time-point measurements. We examined associations of apolipoprotein B (ApoB) relative to LDL cholesterol and diabetes with baPWV prog...

Interactive Media Engagement Predicts Posttraumatic Distress After Community Trauma: A National Repeated Cross-Sectional Study

Objective Media engagement is an important pathway for indirect exposure to community trauma, but little is known about how interactive platforms and meaning-making relate to posttraumatic psychological outcomes. This study examined whether different types of media usage, particu...

Distribution of VerifyNow Aspirin and P2Y12 Reaction Units in Adults Undergoing Preoperative Evaluation: A Single-Institution Retrospective Study

Background: VerifyNow Aspirin and P2Y12 assays (Werfen, Spain) measure residual platelet reactivity and may complement preoperative bleeding-risk assessment, but baseline values of aspirin reaction units (ARU) and P2Y12 reaction units (PRU) in individuals without antiplatelet exp...

Comparative study on the clinical effectiveness of low-concentration cyclosporine eye drops in patients with dry eye disease

Purpose This study aimed to evaluate the efficacy and safety of low-concentration, nanoparticle-based cyclosporine eye drops (SCAI-001 0.01% and SCAI-001 0.02%) compared to those of the conventional Restasis ® (cyclosporine 0.05%) emulsion for dry eye disease (DED). Methods In th...

Dimethylacetamide-Associated Liver Injury in Workers: Clinical Patterns of Latency, Selective Occurrence, and Implications for Occupational Surveillance

OBJECTIVES: N,N-Dimethylacetamide (DMAc) is a widely used industrial solvent and recognized occupational hepatotoxicant. Human evidence, however, appears inconsistent: clinically oriented reports describe overt liver injury in selected workers, whereas large epidemiologic studies...

Survival impact of repeated endobiliary radiofrequency ablation in patients undergoing durvalumab plus gemcitabine and cisplatin for extrahepatic cholangiocarcinoma (BRAVE trial): study protocol for an international multicenter randomized controlled trial

Extrahepatic cholangiocarcinoma (eCCA) often presents with unresectable disease and obstructive jaundice. Systemic therapy with gemcitabine–cisplatin plus durvalumab (GCD) is an international standard; however, the median overall survival (OS) remains about 1 year. Endobiliary ra...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Assessment of Patellar Lateralization and Its Association with Patellofemoral Osteoarthritis Severity: A Retrospective MRI-Based Study

Background/Objectives: Alteration of the anatomy or congruence of the patellofemoral joint may lead to osteoarthritis. The distance of patellar lateralization in a coronal superimposed MR image (coronal MRI superimposition technique) can be a useful method for evaluating patellar...

Predictors of Early Versus Late Atrial Tachyarrhythmia Recurrence After Cryoballoon Ablation by Atrial Fibrillation Type

ABSTRACT Introduction Patient characteristics and predictors of early (ERAT) and late (LRAT) recurrence of atrial tachyarrhythmia by atrial fibrillation (AF) type after cryoballoon ablation (CBA) remain poorly defined. Methods Using the Korean Heart Rhythm Cryoballoon Registry (1...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Evaluating Immunotherapy Outcomes in Elderly Patients with Extensive-Stage Small-Cell Lung Cancer (KCSG LU23-15)

PurposeChemoimmunotherapy has improved outcomes in extensive-stage small-cell lung cancer (ES-SCLC), but its benefit in older adults remains uncertain because this population is underrepresented in clinical trials.We evaluated the real-world efficacy of first-line atezolizumab pl...

Powered Rotational Sheaths in Complex Transvenous Lead Extraction: Comparative Outcomes With Telescoping Sheaths and the WARD‐10 Score

ABSTRACT Background Transvenous lead extraction (TLE) is essential for CIED management and is generally safe with contemporary techniques, although rare cardiac or vascular complications can be life‐threatening. Comparative data between non‐powered telescoping sheaths (TS) and po...

Early On-Treatment Host Fitness Dynamics Refine Prognostic Stratification in Advanced NSCLC Receiving First-Line Immunotherapy

PurposeWe assessed whether baseline and early on-treatment measurements of host fitness using the Prognostic Nutritional Index (PNI) provide complementary prognostic information in advanced non-small cell lung cancer (NSCLC). Materials and MethodsWithin the prospective, multicent...