Kaiser Permanente

Virtual parenting intervention to promote positive parenting and prevent child anxiety and depression symptoms among filipino americanfamilies: protocol for a randomized controlled trial

Filipino youth in the U.S. experience higher rates of depression, suicidal ideation, anxiety, and substance use when compared to other Asian subgroups and non-Hispanic whites, yet are less likely to seek help or receive preventive care. Evidence-based parenting interventions have...

Applying Natural Language Processing to Address Healthcare Bias: Using CARE-SD to Evaluate the Distribution of Stigmatizing Language in Clinical Notes

Electronic health records (EHRs) are a critical medium through which patient stigmatization is perpetuated among healthcare teams. We identified doubt markers and stigmatizing labels in MIMIC-III, a de-identified EHR, via expanded lexicon matching and machine learning classifiers...

Development and Validation of a Novel Algorithm for Classifying Diabetes Type in Adolescents and Young Adults Using Electronic Health Record Data

OBJECTIVE Accurate classification of diabetes type in early-onset populations is essential for epidemiologic and health services research but remains challenging when using electronic health record (EHR) data alone. Our objective was to develop and validate a diabetes typing algo...

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort

Background: Increasing exposure to wildfire fine particulate matter (PM 2.5 ) may pose unique risks to fetal development. We assessed associations between prenatal wildfire PM 2.5 exposure and fetal growth outcomes, including birth weight at term, birth weight for gestational age...

MIR192 upregulates GLP-1 receptor and rescues statin-induced impairment of insulin secretion

Abstract Background Statins are a commonly prescribed cholesterol-lowering drug class that can increase the risk of new-onset diabetes (NOD). The underlying molecular mechanisms have yet to be fully elucidated. We aimed to identify molecular factors associated with differential s...

The Impact of Respiratory Syncytial Virus Undertesting on Estimates of Disease Burden and Vaccine Effectiveness in a Large Integrated Healthcare System

Abstract Infrequent standard-of-care (SOC) testing for respiratory syncytial virus (RSV) in adults with acute respiratory illness (ARI) contributes to underestimated disease burden. We compared RSV prevalence and RSV vaccine effectiveness (VE) among 14,044 adults ≥60 years with A...

Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence

Importance Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems routinely use outreach to promote preventive care, most strategies are static and lack evidence from randomized clinical trials. Objective To determine wh...

Association of lipoprotein(a) with cardiovascular outcomes and breast arterial calcification in postmenopausal women

This study examined the association of lipoprotein(a) [Lp(a)] with breast arterial calcification (BAC) and incident cardiovascular disease (CVD) in postmenopausal women. We analyzed data from 2,799 women in the MINERVA cohort (ages 60–79 years; 34% non-white) free of CVD at basel...

Time-surrogate variables enhance the association between cardiotocographic features and intrapartum hypoxic-ischemic encephalopathy

Abstract Background Interruptions to the flow of oxygenated blood to the fetal brain during labor can lead to hypoxic-ischemic encephalopathy (HIE). Timely preventive interventions for suspected hypoxemia are crucial to avoid progression to neurological injury. Prior research has...

Examining the relationship between D3Cr muscle mass, physical performance, and functional limitation in postmenopausal women

BACKGROUND: The D3-creatine (D3Cr) dilution method provides a non-invasive and accurate assessment of muscle mass. Our objective was to examine the relationship between D3Cr muscle mass, objective measures of physical performance, and self-report physical function postmenopausal...

Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults

BACKGROUND: Whether isolated diastolic hypertension (IDH) in young adults represents a benign, age-specific phenotype or confers increased cardiovascular disease risk remains uncertain. We assessed the associations between hypertension subtypes, IDH, isolated systolic hypertensio...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

Opioid prescription patterns for hidradenitis suppurativa in the emergency versus ambulatory care settings

Abstract Hidradenitis suppurativa (HS) is associated with significant pain. However, there is a paucity of literature examining opioid prescription patterns in HS in different healthcare settings. We aim to determine differences in opioid prescription patterns between HS patients...

Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups

OBJECTIVE Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subseq...

Association of high birth weight with risk of early-onset colorectal cancer

BACKGROUND: Early-onset colorectal cancer (eoCRC), particularly rectal cancer, is increasing. We evaluated the association between high birth weight and eoCRC in a nested case-control study. METHODS: We included patients aged 15-49 years diagnosed with colorectal adenocarcinoma a...

Risk and Protective Factors for Suicidal Ideation and Attempts Among Older Adults in California, 2021–2024 Pooled Cross-Sectional Study

Background/Objectives: Older adults have high rates of suicide, but there is little research on age-specific correlates of suicide. The purpose of this study was to examine risk and protective factors for suicidal ideation and attempts across adult and older adult age groups in a...

Effectiveness of RSV Prevention Strategies in US Infants: 2024–2025

OBJECTIVE: In 2023, 2 products, a long-acting monoclonal antibody (nirsevimab) and maternal respiratory syncytial virus (RSV) vaccination, were recommended in the United States to prevent severe RSV disease among infants in their first RSV season. Low uptake during the 2023 to 20...