Kaiser Permanente

Association of lipoprotein(a) with cardiovascular outcomes and breast arterial calcification in postmenopausal women

This study examined the association of lipoprotein(a) [Lp(a)] with breast arterial calcification (BAC) and incident cardiovascular disease (CVD) in postmenopausal women. We analyzed data from 2,799 women in the MINERVA cohort (ages 60–79 years; 34% non-white) free of CVD at basel...

Time-surrogate variables enhance the association between cardiotocographic features and intrapartum hypoxic-ischemic encephalopathy

Abstract Background Interruptions to the flow of oxygenated blood to the fetal brain during labor can lead to hypoxic-ischemic encephalopathy (HIE). Timely preventive interventions for suspected hypoxemia are crucial to avoid progression to neurological injury. Prior research has...

Examining the relationship between D3Cr muscle mass, physical performance, and functional limitation in postmenopausal women

BACKGROUND: The D3-creatine (D3Cr) dilution method provides a non-invasive and accurate assessment of muscle mass. Our objective was to examine the relationship between D3Cr muscle mass, objective measures of physical performance, and self-report physical function postmenopausal...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults

BACKGROUND: Whether isolated diastolic hypertension (IDH) in young adults represents a benign, age-specific phenotype or confers increased cardiovascular disease risk remains uncertain. We assessed the associations between hypertension subtypes, IDH, isolated systolic hypertensio...

Opioid prescription patterns for hidradenitis suppurativa in the emergency versus ambulatory care settings

Abstract Hidradenitis suppurativa (HS) is associated with significant pain. However, there is a paucity of literature examining opioid prescription patterns in HS in different healthcare settings. We aim to determine differences in opioid prescription patterns between HS patients...

Risk and Protective Factors for Suicidal Ideation and Attempts Among Older Adults in California, 2021–2024 Pooled Cross-Sectional Study

Background/Objectives: Older adults have high rates of suicide, but there is little research on age-specific correlates of suicide. The purpose of this study was to examine risk and protective factors for suicidal ideation and attempts across adult and older adult age groups in a...

Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups

OBJECTIVE Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subseq...

Association of high birth weight with risk of early-onset colorectal cancer

BACKGROUND: Early-onset colorectal cancer (eoCRC), particularly rectal cancer, is increasing. We evaluated the association between high birth weight and eoCRC in a nested case-control study. METHODS: We included patients aged 15-49 years diagnosed with colorectal adenocarcinoma a...

Effectiveness of RSV Prevention Strategies in US Infants: 2024–2025

OBJECTIVE: In 2023, 2 products, a long-acting monoclonal antibody (nirsevimab) and maternal respiratory syncytial virus (RSV) vaccination, were recommended in the United States to prevent severe RSV disease among infants in their first RSV season. Low uptake during the 2023 to 20...