Kagoshima University

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

Using Texture Analysis of US Images to Differentiate Late Neck Lymph Nodes Metastasis to Nonmetastasis in Oral Squamous Cell Carcinoma

ABSTRACT Purpose The purpose of this study was to perform texture analysis of late neck lymph nodes metastases (NLNMs) and non‐NLNMs in postoperative oral squamous cell carcinoma (SCC) on ultrasound (US) images and identify the optimal texture features for distinguishing these ne...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Rapidly enlarging port-site mass after thoracoscopic lung resection: desmoid-type fibromatosis mimicking pleural recurrence

Abstract Background Desmoid-type fibromatosis is a rare, benign fibroblastic neoplasm characterized by infiltrative growth and a tendency for local recurrence despite the absence of metastatic potential. It has been associated with prior trauma or surgery, and postoperative lesio...

Differential Models of Time-Variant Tumor Growth Trajectories with Sensitive, Persister, Resistant Cell Population in Lung Tumors During Tyrosine Kinase Inhibitor Therapy

Modeling the dynamics of three tumor cell populations, i.e., sensitive, persister, and resistant tumor cells, during molecularly targeted therapy with tyrosine kinase inhibitors (TKIs) would be valuable for adjusting treatment plans for patients with epidermal growth factor recep...