Justus-Liebig-Universität Gießen

Tissue Factor Expression Is Associated with Distinct Pattern of Immune-Cell Infiltration in the Ovarian Tumor Microenvironment

Tissue factor (TF) has been implicated in tumor progression and immune regulation, but its cellular sources and relationship with immune infiltration in ovarian cancer remain incompletely defined. We integrated single-cell RNA sequencing (GSE232314), analyses of The Cancer Genome...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

The Influence of Deep Hypothermic Circulatory Arrest on the Incidence of Postoperative Acute Kidney Injury After Pulmonary Endarterectomy

Background: Pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is performed using phases of deep hypothermic circulatory arrest (DHCA). DHCA has been discussed as a risk factor for cardiac surgery-associated acute kidney injury (...

A recurrent neuronal model for the effect of predictions on sensory processes

Predictions, prior knowledge, and expectations strongly influence sensory processing and decision-making, yet the neural mechanisms underlying these effects remain a central question in sensory neuroscience. Although the well-established predictive coding model has gained tractio...

Land use intensification results in abrupt transitions between extensively and intensively managed grasslands

Abstract Understanding whether land use intensification causes regime shifts (i.e. persistent, large changes in ecosystem states) is of key importance for management, particularly if these shifts occur abruptly as thresholds in land use intensity are crossed. Further, these thres...

Eine Auswertung der Publikationsprofile von auf VWL-Professuren Berufenen in Deutschland

Zusammenfassung Kathrin Stock, Peter Tillmann und Andreas Walter analysieren die Publikationsprofile von Volkswirtinnen und Volkswirten, die an deutschen Universitäten auf Professuren berufen worden sind, die zwischen 2014 und 2022 ausgeschrieben waren. Basierend auf Publikations...

The AMIGa complex is at the crossroads of cytochrome c oxidase and ATP synthase biogenesis

Abstract Cytochrome c oxidase (CIV) and ATP synthase are part of the oxidative phosphorylation machinery. Their modular, highly regulated assembly requires specific factors and is coordinated through a common intermediate, the Atco complex, composed of the Atp9 ring and Cox6. By...

Development and Nationwide Multicentre Evaluation of Guideline-Grounded Large Language Model Chatbots to Support Patient Self-Management and Education in Rheumatology

Patients with rheumatic diseases have persistent information needs that are not fully addressed in routine care. We developed and evaluated guideline-grounded, large language model (LLM) chatbots to support patient self-management and education in rheumatology.Ten disease-specifi...

OsteoCHAT: real-world patient evaluation and benchmarking of a guideline-grounded osteoporosis chatbot

Patients with osteoporosis have information needs that routine care inconsistently addresses. In this multicenter real-world evaluation, the LLM-based, guideline-grounded chatbot OsteoCHAT showed high participant acceptability and achieved expert-rated answer quality comparable t...

Amid an Epistemic Iteration: How AI Methodologies May Transform the Nature of Science Education Research

Abstract Advancements in artificial intelligence (AI) may transform the nature of science (NOS). These transformations may extend to science education research, where AI methodologies increasingly enable scalable, reproducible, and fine‑grained analyses of student learning. To re...

Intercellular Transfer of CD155 Mediated by Melanoma Extracellular Vesicles Downregulates DNAM-1 Expression on NK Cells

Melanoma is a highly immunogenic cancer, and immunotherapy is the first-line treatment for patients with advanced disease. However, CD155 overexpression in melanoma has been associated with resistance to immunotherapy. Whether CD155 can be transferred from tumour cells via extrac...

Analysis of sodium self-inhibition of the epithelial sodium channel (ENaC) using classical and medium-throughput automated two-electrode voltage-clamp recordings

Abstract The epithelial sodium channel (ENaC) is a key regulator of electrolyte homeostasis and blood pressure. A characteristic ENaC feature is sodium self-inhibition (SSI), a rapid autoregulatory mechanism in which extracellular Na + ions allosterically bind ENaC and facilitate...

Total en Bloc Urethra Preservation at Robot-Assisted Prostatectomy (ToP-RAP): A Prospective IDEAL Stage 1–2a Study

Background/objective: Urinary continence recovery after robot-assisted radical prostatectomy remains variable despite technical refinements intended to preserve function. We describe Total en bloc Urethra Preservation at Robot-assisted Prostatectomy (ToP-RAP), a technique that pr...

Chikungunya virus uses the tetraspanins CD63, CD9, and CD151 to replicate in human synovial fibroblasts

The arthritogenic alphavirus chikungunya virus (CHIKV) causes debilitating long-lasting joint pain. Host factors used by CHIKV to infect joint cells are largely unknown. Here, we evaluated the role of the 19 tetraspanins expressed in primary human synovial fibroblasts in virus in...

Galectin-3 restrains T cell-driven inflammation in the testis and epididymis

Abstract Galectin-3 (Gal-3) is a pleiotropic molecule involved in immune regulation and tissue homeostasis. While it has been implicated in reproductive tissue function, its role in shaping immune cell dynamics within the testis and epididymis remains incompletely defined. Here,...

Targeting biglycan–TLR2/TLR4 interaction with synthetic peptides mitigates inflammation and ameliorates renal function in ischemia–reperfusion injury

Renal ischemia–reperfusion injury (IRI), characterized by enhanced inflammation, is a leading cause of acute kidney injury (AKI) with limited treatments beyond supportive dialysis. Biglycan through toll-like receptors (TLR)2/TLR4 signaling aggravates tissue damage in acute renal...

Convergence of complex martingales in supercritical multi-type general branching processes in bold italic upper L Superscript bold italic q L q $\boldsymbol{L}^{\boldsymbol{q}}$ for 1 less than bold italic q less than or equals 2 1 < q ≤ 2 $1 \lt \boldsymbol{q} \leq 2$

Abstract Nerman’s martingale plays a central role in the law of large numbers for both single- and multi-type supercritical general branching processes. There are further, complex-valued Nerman-type martingales in the single-type process that figure in the finer fluctuations of t...

POLYHEDRAL COMPACTIFICATIONS OF BRUHAT-TITS BUILDINGS OF QUASI-REDUCTIVE GROUPS

Abstract Given a quasi-reductive group G over a local field k , using Berkovich geometry, we exhibit a family of G ( k ) $G(k)$ upper G left parenthesis k right parenthesis -equivariant compactifications of the Bruhat-Tits building B ( G , k ) $\mathcal B(G, k)$ script upper B le...

b3gbi: Standardized Biodiversity Indicators from Spatiotemporal Occurrence Cubes

Standardized and reproducible biodiversity indicators are essential for tracking ecological trends, assessing conservation policies, and reporting on international biodiversity frameworks. However, raw species occurrence records, such as those hosted by the Global Biodiversity In...

Snakebite Community Map Announcement: Find Research Groups, Clinicians & Organizations Worldwide

Snakebite envenoming remains a neglected tropical disease affecting millions of people annually, yet relevant expertise is scattered and complicated to identify. We introduce a community driven global map connecting researchers, clinicians and organizations across health, researc...