Juntendo University

Additive effects of active vitamin D3 or vitamin E administration on therapeutic lower-limb home exercise for knee osteoarthritis

Background: Quadriceps weakness, inflammation, and reduced physical function are common in knee osteoarthritis (OA), and lower limb exercise therapy is an established non-pharmacological treatment. Vitamin D3 (vit D3) and vitamin E (vit E) have been proposed as adjunctive therapi...

Variable clinical course of retinitis pigmentosa patients with RPE65 gene mutations

This retrospective observational study characterized the clinical features and visual function of early- and later-onset retinitis pigmentosa (RP) caused by biallelic variants in the RPE65 gene ( RPE65 -RP). Nine genetically confirmed patients (seven unrelated individuals and one...

Developing a Comprehensive Public Health Nursing Practice Model for Promoting Social Inclusion Among Populations Experiencing Social Exclusion: A Qualitative Study

ABSTRACT Aims To develop a comprehensive practice model delineating public health nursing practices that promote social inclusion and illustrate their outcomes in Japan. Design Qualitative descriptive research design. Methods Semi‐structured interviews were conducted with 12 publ...

Gauss law constraint in A-theory branes

{\cal A} -theory realizes U-duality symmetry by extending the string worldsheet to a higher dimensional brane worldvolume, in which the worldvolume and the spacetime belong to different representations of the exceptional group. The closure of the brane Virasoro algebra requires t...

Development of YO-01027-Derived Signal Peptide Peptidase Inhibitors with Reduced γ-Secretase Inhibition

Abstract Signal peptide peptidase (SPP) is an endoplasmic-reticulum intramembrane aspartyl protease required for hepatitis C virus (HCV) core protein maturation, but many SPP inhibitors also inhibit γ-secretase. Here, we designed YO-01027-derived dibenzazepinone analogs to retain...

Development of a support system for total hip arthroplasty: evaluation of lower limb loads using virtual and dummy human body models

Abstract Purpose The direct anterior approach (DAA) is one of the procedures used for total hip arthroplasty (THA) and offers advantages such as faster postoperative recovery. A lower limb traction operating table has been developed to assist in intraoperative movement and retent...

Fatal Dilated Cardiomyopathy and Monogenic Diabetes Mellitus as SMPD4 ‐Related Disorder

ABSTRACT Sphingomyelin phosphodiesterase 4 (SMPD4)‐related disorder is a rare neurodevelopmental disorder caused by biallelic loss‐of‐function variants in SMPD4, characterized primarily by severe neurological manifestations. A subset of long‐term survivors develops diabetes melli...

Impact of third-party accreditation and general medicine in-training examination participation on residency program popularity: a nationwide matching data analysis in Japan

Abstract Background Third-party accreditation and the visibility of educational outcomes may influence medical students’ choice of training sites; however, national evidence of their effect in Japan is limited. This study examined whether hospital characteristics—especially Japan...

On the Conservativeness of Robust Variance Estimators in Propensity Score Weighted Cox Models

In propensity score weighted analysis, robust variance that does not account for weight estimation (hereafter, uncorrected variance) is commonly used. In propensity score weighted Cox models (CoxPSW), the uncorrected variance is known to be conservative when weights for the avera...

Atlas of cell types and regulatory elements underlying human facial diversity

Abstract Human genetic diversity generates an astonishing variety of facial shapes, and craniofacial anomalies rank among the most common birth defects. Identifying the cellular mechanisms that mediate the genome’s influence on facial variation remains a challenge. Here we create...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

Evaluation of clinical performance of artificial intelligence-assisted measurement of thoracic aortic diameter on non-contrast CT

This study aimed to evaluate the clinical performance of artificial intelligence (AI)-assisted measurement of thoracic aortic diameter on non-contrast computed tomography (NCCT). This single-center prospective study included 79 patients (mean age = 70 ± 13 standard deviation; 46...

Modular assembly of arterial organoids enables rapid blood perfusion to ameliorate ischemic diseases

Abstract Transplantation of vascular cells is a potential strategy for enhancing vascular regeneration in the treatment of ischemic diseases. However, its therapeutic application is limited by poor engraftment and insufficient vascular integration. Here, we develop a scalable met...

Network impact assessment and stability enhancement through Markov chain analysis and load balancing

Abstract This study proposes a methodology for analyzing and improving network stability using discrete Markov chains. By modeling device transitions in network logs as Markov chains, we developed two models: a Network Impact Assessment Model and a Network Stability Optimization...

Association between Work Engagement and Obesity among Workers in a Large Japanese Company

OBJECTIVE: To clarify the association between work engagement and obesity among workers. METHODS: This cross-sectional study assessed 20,611 workers in a large Japanese company. We assessed work engagement, obesity (BMI ≥ 30 kg/ m 2 ), and overweight (BMI ≥ 25 kg/ m 2 ). Multivar...

Osteoporosis in internal medicine outpatients: Sex-specific disparities in prevalence, risk stratification, and treatment in a large cohort

Abstract Background Osteoporosis is a major health problem linked to population aging. Internal medicine outpatients often have multiple comorbidities and a high osteoporosis risk; however, osteoporosis prevalence and treatment rates remain unclear. We investigated osteoporosis p...

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

BACKGROUND: Evidence of the diverse genetic architecture of dilated cardiomyopathy (DCM) continues to emerge and requires reassessment of the clinical relevance of implicated disease genes. Building on the 2019-2020 Clinical Genome Resource evaluation, the DCM gene curation exper...

Effects of the Institutional Volume of Endovascular Treatment for Lower Extremity Artery Disease on Radiation Exposure

Purpose: The procedure time of endovascular treatment (EVT) for lower extremity artery disease (LEAD) may increase as its application expands to more complex lesions. Given this trend and the growing importance of radiation protection, this study investigated the association betw...

Impaired liver-muscle lactate metabolism causes sarcopenia via lactic acidosis in skeletal muscle in mice

Sarcopenia is a progressive disease characterized by age-related decline in skeletal muscle force and mass. The fundamental molecular pathogenesis of sarcopenia has not yet been elucidated. Here, we show that the accumulation of lactate and intracellular acidification, lactic aci...

Minimally invasive cardiac surgeries in 2023–annual report of the Japanese association for minimally invasive cardiac surgery

Abstract Objective To establish updated nationwide perioperative benchmarks for minimally invasive cardiac surgery (MICS) in Japan by presenting the 2023 annual report and summarizing procedural trends from 2021 to 2023. Methods Data on mitral valve (MV) surgery, aortic valve rep...