John Radcliffe Hospital

Knotless Suture Repair For Chronic Lateral Ankle Instability: A Systematic Review and Single-Arm Meta-Analysis

Introduction There is a need to assess the use of knotless sutures in cohorts with chronic ankle instability (CAI). Methods A literature search of Embase, Ovid MEDLINE, Cochrane Library and Scopus was conducted from each database’s inception to August 15, 2025. Eligible studies r...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

Serum NfL predicts visual recovery and neuronal loss after optic neuritis

Optic neuritis, a common manifestation of multiple sclerosis, involves acute axonal injury and variable visual recovery. We evaluated whether serum neurofilament light chain predicts visual and structural outcomes after first-episode optic neuritis. Fifty-one patients (mean age =...

Test-retest reliability of plasma biomarkers and digital cognitive metrics at clinically meaningful timescales

Abstract Background Digital cognitive testing and plasma biomarkers have emerged as key players for population screening and measuring drug efficacy in clinical trials for Alzheimer’s Disease (AD). Understanding test-retest reliability of these tools is essential to estimate mean...

Decoding spatial mTOR signalling reveals distinct roles in the tumour microenvironment

Abstract The tumour microenvironment comprises a variety of cell types that interact with malignant cells, influencing both cancer progression and the patient response to therapy. Given the intricate interactions among these components, assessing how signalling pathways contribut...

Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study

BACKGROUND: The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in care and survival for people with thoracic aortic disease (TAD) in England. METH...

Total intravenous versus volatile anesthesia in living donor hepatectomy: A global prospective cohort study from the international LDLT registry

The choice between total intravenous anesthesia (TIVA) and volatile anesthesia for living donor hepatectomy remains controversial, with limited evidence comparing their impact on donor and recipient outcomes. This study evaluates the association between anesthetic technique and e...

Management of choking in Motor Neuron Disease: patient and public involvement in a co-produced mixed-methods study protocol

Abstract Background Up to 70% of people living with Motor Neuron Disease (plwMND) report distressing episodes of choking (a feeling of suffocation or airways blockage) due to involvement of bulbar muscles. There is an evidence gap on management of choking in plwMND, which is mirr...

Comparison of current treatment strategies for AMD-related submacular haemorrhage: Real-world outcomes

Abstract Purpose Comparison of available treatment modalities for neovascular AMD-related submacular haemorrhage including robot-assisted subretinal drug delivery. Methods Single centre, long-term, retrospective analysis of patients treated for nAMD-related submacular haemorrhage...

Myalgic encephalomyelitis/chronic fatigue syndrome and overlapping post-acute infection syndromes: international expert consensus framework for diagnostic standardization

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks validated objective diagnostic criteria, leading to delayed diagnosis and inconsistent management. We aimed to establish an international expert consensus framework integrating measurable, risk-stratified assessmen...

Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice

Background Most mutations causing hypertrophic cardiomyopathy (HCM) affect sarcomeric proteins. Mutations in junctophilin-2 (JPH2) are also implicated, but the underlying mechanisms remain unclear. An A405S variant in JPH2 was identified in a male adolescent patient with interven...

Lipemia Retinalis Reversal in Familial Partial Lipodystrophy

This case report describes a diagnosis of lipemia retinalis in a woman aged 27 years with creamy discoloration of the retinal vessels on fundus examination and markedly elevated serum triglyceride levels.

A novel framework for quantifying the clinical impact of substandard and falsified antimicrobials: Application to typhoid fever

Substandard and falsified (SF) medicines are a neglected public health threat, with an estimated 7% of antimicrobials in low- and middle-income countries being SF. However, quantifying their clinical impact remains challenging. We developed a general framework for estimating popu...

Public perceptions of polygenic testing and embryo selection for non-medical traits

Abstract Some advances in reproductive technologies raise substantial ethical and psychological challenges, for example, the use of preimplantation genetic testing to select embryos based on non-medical traits. While studies have explored public willingness to use preimplantation...

Concordance of genetic determinants of acute coronary artery disease between European and Chinese populations

AIMS: This study examined the concordance of associations of single nucleotide polymorphisms (SNPs) for acute coronary artery disease (CAD) discovered in Europeans with acute CAD, chronic ischaemic heart disease (IHD) or stroke in Chinese adults. METHODS: In a nested case-control...