John Cochran VA Medical Center

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

Abstract Background Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiac myocytes, and mutations in PQC pathway proteins, such as CRYAB (arginine to glycine at position 120, R120G) and BAG3 (proline to lysine at position 209, P209L...

Real-World Experience of Hepatitis C Treatment With Glecaprevir-Pibrentasvir During Pregnancy.

Guidelines endorse antenatal hepatitis C virus treatment following shared decision making. No clinical trial or real-world data exist for glecaprevir-pibrentasvir (GLE/PIB). We report our experience with prenatal GLE/PIB in 14 patients. Ten patients completed treatment; all achie...