Jinnah Sindh Medical University

Comparative Effectiveness and Safety of Denosumab Versus Bisphosphonates in the Management of Osteoporosis: A Systematic Review and Meta-Analysis

Osteoporosis is a widespread bone disorder, as the bone strength is decreased, bone microarchitecture deteriorates, and an increased risk of fragility fracture occurs, especially in the elderly and postmenopausal women. Anti-resorptive drugs, such as bisphosphonates and denosumab...

Dexamethasone versus triamcinolone acetonide for the management of postoperative inflammation following cataract surgery

Background: Cataract remains the leading cause of reversible blindness worldwide, particularly in low-resource settings. Effective control of postoperative inflammation is essential to prevent complications such as cystoid macular edema and raised intraocular pressure. Dexamethas...

Efficacy and Safety of Cisplatin Versus Carboplatin for Patients With Squamous Cell Carcinoma of Head and Neck: A Systematic Review and Meta‐Analysis

ABSTRACT Background Cisplatin‐ and carboplatin‐based regimens are widely used in the treatment of head and neck squamous cell carcinoma (HNSCC), yet comparative evidence on survival and toxicity outcomes remains limited. While cisplatin is standard in many settings, carboplatin i...

High-flow nasal cannula versus conventional oxygen therapy in adults with acute hypoxemic respiratory failure: an updated systematic review, meta-analysis and trial sequential analysis

HFNC oxygen therapy is widely used for acute hypoxemic respiratory failure (AHRF), yet its superiority over conventional oxygen therapy (COT) remains uncertain. This meta-analysis evaluated HFNC efficacy and safety in adults with AHRF. Five databases were searched from January 20...

Health Literacy, Antibiotic Use Behaviors, and Awareness of Antimicrobial Resistance Among Patients in Karachi, Pakistan

Background: Antimicrobial resistance (AMR) is a public health problem that is emerging due to inappropriate use of antibiotics and a lack of public awareness. The aim was to evaluate the knowledge, awareness, attitudes, and practices of patients attending a tertiary care hospital...

National mortality trends due to OSA and respiratory failure in U.S adults from 1999–2023

Obstructive sleep apnea (OSA) and respiratory failure (RF) represent increasing clinical and public health challenges in the United States, yet national trends in mortality remain underexplored. This study evaluates trends in mortality associated with OSA and RF to highlight targ...

Post-Procedural Angiography-Based Physiological Indices and Clinical Outcomes After Drug-Coated Balloon Treatment of In-Stent Restenosis

Drug-coated balloons (DCBs) represent an accepted approach for in-stent restenosis (ISR); however, post-procedural predictors for risk stratification remain limited. Angiography-based physiological parameters, including quantitative flow ratio (QFR), microvascular QFR (μQFR), and...

Carvedilol for prevention of cardiotoxicity in patients receiving anthracycline-based chemotherapy: a systematic review and meta-analysis

Chemotherapy-induced cardiotoxicity, particularly from anthracyclines, limits treatment in oncology patients. Carvedilol, a third-generation β-blocker with antioxidant properties, may offer cardio protection. However, comparative evidence for carvedilol and its metabolites remain...

Angiography-Derived vs Wire-Based Physiological Assessment in Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This study aimed to determine whether angiography-based physiological assessment yields clinical outcomes comparable to those of conventional wire-based pressure measurements in patients with coronary artery disease (CAD) undergoing evaluation of intermediate coronary stenoses. A...

Pulsed Field Versus Cryoballoon Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis

In the treatment of atrial fibrillation (AF), cryoballoon ablation (CBA) is associated with a high incidence of pulmonary vein reconnection, potentially limiting long-term efficacy. Pulsed field ablation (PFA) has emerged as a promising alternative with the potential for improved...