Jiangsu Provincial Center for Disease Control and Prevention

FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss

Background: Noise-induced hearing loss (NIHL) is a pervasive occupational health challenge, yet the individual susceptibility mechanisms remain unclear. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in cochlear hair cell damage. This study aims...

Sex differences in neurogenic hypertension: estrogen modulation of NADPH oxidase signaling in the rostral ventrolateral medulla

Abstract Neurogenic hypertension is characterized by sustained sympathetic activation arising from dysregulation within the central autonomic network. The rostral ventrolateral medulla (RVLM) is a major sympathetic premotor region that integrates reflex, neurohumoral, inflammator...

Photonic-crystal hydraulic manometry quantifies epithelial basal compression for rapid, label-free functional screening

Polarized epithelia integrate barrier sealing, vectorial ion-water transport, and cytoskeletal mechanics, yet scalable assays that report this coupled functional state in real time remain limited. Here, we introduce photonic-crystal hydraulic manometry (PCHM), which quantifies ou...

Per- and PolyfluoroalkylSubstances in Pediatric CerebrospinalFluid: Evidence of Central Nervous System Exposure

Abstract Per- and polyfluoroalkyl substances (PFAS) have been implicated in neurodevelopmental toxicity, yet direct evidence of their presence within the central nervous system (CNS) of children remains limited. We quantified 12 PFAS in cerebrospinal fluid (CSF) samples from 47 p...

Environmental exposure to semi-volatile organic compounds and COPD progression: Evidence mapping, exposure assessment and metabolomic insights

Introduction Chronic obstructive pulmonary disease (COPD) progression may be influenced by non-smoking environmental exposures, especially among never-smokers and environmentally exposed populations. Semi-volatile organic compounds (SVOCs) are relevant because they persist in air...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...

The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-bli...