Iuliu Hațieganu University of Medicine and Pharmacy

Dimensional accuracy and flexural strength of 3D-printed photopolymer resins for point-of-care surgical guides after steam and plasma sterilization: an in-vitro comparative study

Abstract Background Three-dimensional (3D) printing enables the fabrication of patient-specific guides (PSGs) for oral and craniomaxillofacial procedures. Before clinical use, guides must be sterilized, which may compromise dimensional accuracy and mechanical performance. The eff...

Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates

Background/Objectives: We assessed changes in nonfatal disease burden and risk attribution in Romania between 1990 and 2023. Methods: We analysed Global Burden of Disease (GBD) 2023 estimates of years lived with disability (YLDs), related nonfatal measures and risk attribution fo...

The Epigenetic Architecture of Classical Hodgkin Lymphoma: Lineage Erasure, Immune Escape, and Therapeutic Reprogramming

Classical Hodgkin lymphoma (cHL) is distinguished by a rare population of Hodgkin and Reed–Sternberg (HRS) cells that has largely extinguished its germinal center (GC) B-cell identity while maintaining survival, immune escape, and dependence on a highly organized tumor microenvir...

Twenty-Five Years of Human Urinary Biomonitoring of Mycotoxins: Analytical Advances and Applications in Risk Assessment

Mycotoxins are secondary fungal metabolites that have continuously attracted research interest, both for their potential negative effects on animal and human health and for the economic losses they entail. Studies assessing exposure to mycotoxins have become increasingly widespre...

Impact of postoperative pulmonary complications on survival after gastrectomy for cancer: individual patient data meta-analysis

Abstract Background Pulmonary complications (PC) may occur in up to 6.8% of patients after gastrectomy. Although PC are associated with prolonged hospital stay and increased overall healthcare costs, their impact on long-term survival remains controversial. This study aimed to an...

Voice-Based Screening of Depression and Anxiety Using Machine Learning and Deep Learning: A Scoping Review of Methods and Clinical Readiness

Despite the high global prevalence of depressive and anxiety disorders, access to early clinical assessment remains limited for many. Although this field has grown rapidly, existing reviews have focused primarily on technical performance, with limited systematic attention to whet...

Comparison of the Alvarado Score with Alternative Diagnostic Tools in Pediatric Acute Appendicitis: A Literature Review

Background: Acute appendicitis is a leading pediatric surgical emergency. Timely diagnosis remains challenging, particularly in young children with atypical presentations. Clinical evaluation alone yields variable diagnostic performance, prompting the use of risk stratification t...

Metabolic Syndrome and Pancreatic Cancer: Linking Insulin Resistance, Inflammation, and Carcinogenesis

Metabolic syndrome (MetS) is a composite classification defined by heterogeneous combinations of cardiometabolic abnormalities. Several components have been associated with pancreatic cancer (PC), but studies often conflate long-term metabolic exposure, tumor-related prediagnosti...

Beyond One-Size-Fits-All: Individually Tailored Dietary Interventions in Modern Obesity Care

Obesity is a complex, multifactorial chronic disease characterized by excessive and/or aberrant adiposity that requires interventions beyond conventional calorie-restriction models. Current clinical guidelines converge on behavioral modification, encompassing nutritional therapy,...

Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson’s Disease: A Critical Review of Mechanistic Rationale and Biomarker Stratification

Background: Parkinson’s disease (PD) exhibits remarkable clinical heterogeneity, with substantial variability in motor progression, cognitive decline, and the development of non-motor manifestations. Although the propagation of pathological alpha-synuclein is considered a central...

Bloating after Silicone Breast Implants

BACKGROUND AND AIM: Empirical data suggest that women submitted to silicone breast implant surgery report bloating after intervention. We aimed to look to this phenomenon in a retrospective study. METHODS: An online ad-hoc survey was created. It included 22 items aiming to collec...

The Cost of the Cure: Antibiotic Exposure as a Risk Factor for Irritable Bowel Syndrome

The intricate interplay between the gut microbiome and the enteric nervous system remains a paramount focus in understanding the multifactorial pathogenesis of disorders of gut–brain interaction (DGBI), most notably irritable bowel syndrome (IBS). While the clinical entity of pos...

Perceived Stress and Domain-Specific Physical Activity in Relation to Anxiety and Somatic Symptom Burden Among Romanian Adults: A Cross-Sectional Online Survey

Background and Objectives: Physical activity may relate to mental health differently depending on whether it is performed at work, for transport, or during leisure. Evidence regarding this distinction in Romanian community samples remains limited, and it is unclear whether these...

Beyond the biopsy: the new era of non-invasive staging and biomarkers in colorectal cancer

Colorectal cancer (CRC) management is increasingly challenged by shifting demographics, notably the rise in aggressive early-onset CRC, and the limitations of conventional anatomical staging. This comprehensive review explores the paradigm shift toward noninvasive and minimally i...

Emotional Stability and Emotional Eating in Medical Students: Exploring Indirect Associations Involving Anxiety and Depressive Symptoms

Background/Objectives: Emotional stability is a personality trait associated with emotion regulation and adaptation to stress. Low emotional stability has been associated with anxiety, depressive symptoms, and emotional eating, but the mechanisms underlying these relationships am...