Iuliu Hațieganu University of Medicine and Pharmacy

Limited Gut Microbiome Differences Between Relapsing–Remitting and Secondary Progressive Multiple Sclerosis: A Shotgun Metagenomic Study

The gut microbiome may contribute to multiple sclerosis (MS) pathophysiology, but its relationship with disease phenotype and progression remains unclear. To characterize taxonomic and functional gut microbiome differences between relapsing–remitting MS (RRMS) and secondary progr...

Sinus Floor Elevation Magnitude and Longitudinal Peri-Implant Marginal Bone Change over a Minimum Five-Year Follow-Up: A Retrospective Cohort Study

Background/Objectives: The magnitude of maxillary sinus floor elevation may reflect site anatomy and surgical complexity, but its association with peri-implant marginal bone change remains unclear. This study evaluated whether elevation magnitude was associated with longitudinal...

Food, Dietary Supplement, and Gut Microbiome Interactions in Oral Anticancer Therapy: Mechanisms, Clinical Consequences, and Management

BACKGROUND: The shift toward oral targeted therapies and immune checkpoint inhibitors (ICIs) in oncology has introduced pharmacokinetic variability driven by food-drug interactions (FDIs), which can cause therapeutic failure or increased toxicity. AREAS OF UNCERTAINTY: FDI effect...

Structure–Property Relationships in Bioactive Poly (Vinyl Alcohol) Films Incorporating Natural Phenolic Additives for Sustainable Active Packaging

This study aimed to investigate bioactive poly (vinyl alcohol) (PVA) films incorporating three chemically distinct naturally phenolic additives—aronia extract (A), apple peel extract (AP), and rutin (R)—as individual functional modifiers for active packaging applications. Here, w...

Pre-registered analysis plan and frozen code: apparent speed, direction and origin of an epidemic wave

The registration, before any data value of the two test datasets was seen, of the hypotheses, the decision rules, the data preparation and the complete analysis code of a methodological study: how the speed, direction and origin of an epidemic wave are estimated from surveillance...

Vascular Phenotyping Across the CKM Syndrome: Arterial Stiffness and Endothelial Function Testing, Prognostic Value and Clinical Implementation

Cardiovascular–kidney–metabolic (CKM) syndrome represents a continuum of metabolic, renal, and cardiovascular abnormalities in which vascular dysfunction may develop before clinically overt cardiovascular disease. Endothelial dysfunction, arterial stiffness, microvascular abnorma...

The Left Atrial Appendage: Anatomy, Electrophysiology, and Clinical Implications for Atrial Fibrillation and Stroke

Abstract Purpose of Review The left atrial appendage (LAA) is nowadays recognized as both an arrhythmogenic substrate and the dominant source of thromboembolism in atrial fibrillation (AF). In this review we tried to summarize recent data on the anatomy, physiology, and imaging o...

A review on laser-assisted veneer debonding

This literature review examines the advancements in laser technology that have enhanced the veneer debonding process, offering insights into the proper implementation of these techniques in clinical practice with emphasis on laser parameters, debonding efficiency, thermal effects...

Somatic Blood Mosaicism and Psychiatric Disease: Current Evidence and Causal Limits

Somatic blood mosaicism is an established feature of ageing and a heterogeneous marker of haematologic cancer and inflammatory and vascular risk, but its psychiatric evidence base remains small. This structured critical narrative review evaluates mutation-defined clonal haematopo...

BDNF Val66Met (rs6265) in Ankylosing Spondylitis: A Descriptive Genotype–Phenotype Study in a Romanian Cohort

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease with musculoskeletal and extra-articular manifestations and associated cardiometabolic comorbidity. Brain-derived neurotrophic factor (BDNF) is involved in pain processing, neuroplasticity, inflammatory sig...

Skill maintenance in neurosurgery: lessons from high-reliability professions and a plea to prioritize psychomotor skill retention, a mini-review

Microsurgical procedures in neurosurgery are characterized by steep learning curves, exceptional technical complexity, and limited tolerance for error. While considerable research has focused on microsurgical skill acquisition and the development of training models, substantially...

Interferon-enhanced cytokine responsiveness in early trauma-induced immune dysfunction: a prospective observational pilot study

Severe trauma induces profound alterations in innate and adaptive immunity within hours after injury, which may contribute to increased susceptibility to secondary infections and adverse outcomes. While trauma-associated immune dysfunction has been extensively described, little i...

Real-World Clinical Management of Keratoconus in Europe and the Middle East: A Multicountry Survey on Diagnostic and Surgical Practices (Keratoconus in Mind - KIM Project)

Purpose: This study aimed to describe the current management of patients with keratoconus in European and Middle Eastern countries through the collection of real-world data from clinicians actively managing keratoconus. Methods: Computer-assisted web interviewing survey targeting...

Minimalist Footwear and Knee Joint Loading During Walking in Healthy Adults: A Systematic Review of Evidence for Osteoarthritis Prevention

Background/Objectives: Minimalist footwear has been proposed as a passive means of reducing knee loading, but its effects during walking in healthy adults, the population relevant to primary prevention of knee osteoarthritis (KOA), have not previously been synthesized. Methods: F...

Local and Systemic Risk Factors of Dental Biofilm‐Induced Gingivitis and Their Control: A Systematic Review

ABSTRACT Objectives To identify local and systemic risk factors/indicators for dental biofilm‐induced gingivitis (DB‐GI) and to summarize evidence for their control. Methods A systematic review was undertaken following Preferred Reporting Items for Systematic Review and Meta‐Anal...

Longitudinal Stability of the Gut Microbiota in Relapsing–Remitting Multiple Sclerosis: A Prospective Observational Study

The gut microbiota plays a key role in immune regulation in multiple sclerosis (MS), yet longitudinal data on microbiome dynamics and their relationships with disability and biomarkers remain limited. This study aimed to identify longitudinal gut microbiome changes in patients wi...

The Role of Artificial Intelligence in Optimizing Diagnosis in Prostate Cancer—A Narrative Review

Artificial intelligence (AI) is increasingly being investigated in prostate cancer (PCa) diagnosis and characterization, offering novel approaches to improve detection and risk stratification. This narrative review summarizes current evidence regarding the application of AI acros...

Plant-Based Diets in Adolescence: Cardiometabolic Benefits, Developmental Risks, and the Role of Fortification

Adolescence is a critical window in which dietary patterns stabilise while nutrient requirements remain high to support growth, bone accrual, and neurodevelopment. Plant-based diets are increasingly adopted by young people, yet paediatric evidence indicates that they should not b...

Association of Preoperative Personality Traits with Six-Month Subjective Quality of Vision After Bilateral PanOptix Trifocal IOL Implantation: A Prospective Single-Center Study

Purpose: To investigate the association between preoperative personality traits and subjective quality of vision six months after bilateral trifocal intraocular lens (IOL) implantation. Methods: This prospective, single-center study included 66 patients undergoing bilateral impla...

Dimensional accuracy and flexural strength of 3D-printed photopolymer resins for point-of-care surgical guides after steam and plasma sterilization: an in-vitro comparative study

Abstract Background Three-dimensional (3D) printing enables the fabrication of patient-specific guides (PSGs) for oral and craniomaxillofacial procedures. Before clinical use, guides must be sterilized, which may compromise dimensional accuracy and mechanical performance. The eff...