Italian Institute of Technology

Configuration-space Bayesian optimisation for stress-critical pose identification on a hyper-redundant robot

Abstract Serial manipulators can have strongly varying internal stresses within their configuration space, making the identification of stress-critical poses important for structural design.Because each candidate configuration requires a computationally expensive Finite Element A...

Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.

Background: Prevailing theories propose that autism is characterized by local cortical overconnectivity and long-range underconnectivity, but empirical evidence remains mixed. Methods: = 1009) to examine how functional synchronization profiles dynamically change over time and acr...

Alpha and beta event-related synchronization as neural markers of self-other processing during sensorimotor coordination

Interpersonal synchrony requires continuously balancing internally generated timing predictions with externally driven adjustments to a partner's behavior. Neural oscillations in alpha and beta bands have been implicated in prediction processes during joint action, yet their role...

The isolated HEPN domain of SACSIN exhibits RNA-binding activity

Abstract Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS) is a neurodegenerative disorder caused by mutations in the SACS gene, though the molecular function of its protein product, SACSIN, remains elusive. Therapeutic strategies for ARSACS are limited, mostly d...

The Mind From Within: Visceral Roots of Human Cognition

ABSTRACT Humans think and act not only with the brain but also with the heart, lungs, gut, and other viscera, such as the bladder, long regarded as primarily vegetative. A fresh wave of experiments is revealing the role of cardiac‐cycle phase and baroreceptor firing in perception...

BIDS Extension Proposal 40 (BEP040): fUSI-BIDS

This specification extends the Brain Imaging Data Structure (BIDS) Specification for functional ultrasound imaging (fUSI) of the brain. The fUSI-BIDS specification is designed to standardize collections of ultrafast power Doppler scans acquired using any functional ultrasound ima...

BIDS Extension Proposal 40 (BEP040): fUSI-BIDS

This specification extends the Brain Imaging Data Structure (BIDS) Specification for functional ultrasound imaging (fUSI) of the brain. The fUSI-BIDS specification is designed to standardize collections of ultrafast power Doppler scans acquired using any functional ultrasound ima...

Mapping the NFYA 3′UTR landscape identifies alternative polyadenylation as a targetable vulnerability in prostate cancer

Abstract Background Alternative polyadenylation (APA) is increasingly recognized as a pervasive oncogenic mechanism that reshapes post-transcriptional gene regulation and promotes tumor aggressiveness. Whether APA contributes to the dysregulation of NFYA —encoding the regulatory...

Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection

<title>Abstract</title> Intracellular pathogens are ideal candidates for modelling the pathophysiology of chronic infection, as they hide within host cells and avoid conventional immune clearance through a controlled reshaping of cellular fate. This study unveils how the emerging...

The quest for the optimal level of sense of agency in the case of human-operated, AI-enabled robotics

Sense of agency is the subjective feeling of being in control over one’s own actions and their sensory outcomes. Here, we propose that a key feature of sense of agency is its link to intrinsic motivation, which is a key driver for engagement with the environment without external...

Characterizationof Airborne Emissions and PreliminaryIn Vitro Toxicity Screening of Polyamide 12 Used in Additive Manufacturing

Abstract Polyamide 12 (PA12) is a widely employed feedstock material in industrial additive manufacturing (AM) technologies. Despite this, there is limited epidemiological evidence regarding its health effects, raising particular concern about the potential implications for worke...

Susceptibility haplotypes in non-cystic fibrosis newborns with elevated immunoreactive trypsinogen

Cystic fibrosis (CF) represents the most prevalent life-threatening autosomal recessive disorder in Europe, primarily affecting the respiratory tract, exocrine pancreatic function, and lipid metabolism. Immunoreactive trypsinogen (IRT) quantification constitutes the first-tier te...

Intraoperative and postoperative management in endoscopic ear surgery: Perspectives from a worldwide survey

PURPOSE: To examine intraoperative and postoperative practices (antibiotic and antithrombotic prophylaxis, ear packing, behavioural recommendations, follow-up strategies) in exclusive endoscopic ear surgery management, based on a global survey of experienced surgeons. METHODS: Th...