Istituto Ortopedico Rizzoli

Transarterial embolization in inflammatory arthritis: will rheumatology shape the debate or inherit it?

Abstract The expanding use of transarterial embolization for musculoskeletal pain, most commonly operationalized as genicular artery embolization in osteoarthritis, raises a broader question that rheumatology has not yet systematically addressed: might a vessel-targeted, image-gu...

Risk factors for treatment failure of surgical site deep infections following spinal instrumentation: multicentre observational study (DeFEndO study)

Introduction : To describe the characteristics and outcome of patients diagnosed with deep surgical-site infections following spinal instrumentation (DSIIs) and to investigate risk factors for treatment failure including antimicrobial treatment duration as the main exposure. Mate...

Autologous Collagen-Induced Chondrogenesis (ACIC) for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis

Background and Objectives: Autologous Collagen-Induced Chondrogenesis (ACIC) is a regenerative technique for treating osteochondral lesions that combines microfracture with the application of an injectable atelocollagen scaffold over the defect. This scaffold stabilizes the marro...

DARE to wear: digital health promotion and disease prevention using wearable devices

Global healthcare systems are under increasing strain to ensure long-term sustainability, necessitating a transition towards proactive, preventive healthcare strategies. Wearable sensor technologies are uniquely positioned to facilitate this paradigm shift by allowing continuous...

Higher prearthritic activity is associated with higher long‐term activity after medial unicompartmental knee arthroplasty

Abstract Purpose To evaluate long‐term sport participation after medial unicompartmental knee arthroplasty and determine whether recalled prearthritic activity was associated with activity at final follow‐up. Methods This retrospective study included 76 knees in 70 patients evalu...

Real-world effectiveness and drug retention rate of risankizumab in patients with psoriatic arthritis: data from the multicentre GIRRCS cohort

Introduction Psoriatic arthritis (PsA) is a chronic heterogenous inflammatory disease characterized by a multidomain burden. Risankizumab, a selective inhibitor of the IL-23 p19 subunit, has shown efficacy in randomized trials; however, real-world data in PsA remain limited. We e...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Predicting the risk of dehydration and readmission among rectal cancer patients with ileostomy: a multicenter observational study

Abstract Dehydration is a frequent complication among rectal cancer patients after ileostomy, often resulting in hospital readmission. The Dehydration Readmission after Ileostomy Prediction (DRIP) score was used to identify patients at risk of dehydration-related readmission. The...

Clinical Relevance of Calcifications in Osteosarcoma Lung Metastases: Correlations Among Radiological Patterns, Histological Subtypes, and Chemotherapy Responses

Background/Objectives: Osteosarcoma is a rare malignancy and the most common primary malignant bone tumor. Metastases commonly affect the lungs and are associated with reduced life expectancy. Calcifications can be present within a metastatic nodule at baseline or can appear duri...

Neanderthal’s heel: How the Neanderthal’s external calcaneal shape uniquely differs from that of modern humans

Neanderthals exhibit unique morphological adaptations in their calcaneus compared to Homo sapiens , shedding light on distinct evolutionary pressures and functional requirements shaping their respective foot anatomy. This study assesses which calcaneal traits represent plesiomorp...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

Progressive Hallux Pain Due to Subungual Exostosis: Diagnosis and Surgical Management

Background and aim Subungual exostosis is a relatively uncommon benign ostecartilaginous lesion of the distal phalanx of the great toe, responsible for pain and nail deformity. Material A case of subungual exostosis in a female patient is reported. Diagnosis was made performing c...

Chondrosarcoma of the mobile spine: impact of tumor status at referral and surgical strategy on oncological outcome

BACKGROUND: Chondrosarcoma (CHS) is a rare malignant bone tumor, mostly histologically low grade, demonstrating limited response to chemotherapy and conventional photon radiotherapy (RT). According to Enneking Staging System, tumor-free margin en bloc resection is the cornerstone...