Istituto Ortopedico Gaetano Pini

Progressive Hallux Pain Due to Subungual Exostosis: Diagnosis and Surgical Management

Background and aim Subungual exostosis is a relatively uncommon benign ostecartilaginous lesion of the distal phalanx of the great toe, responsible for pain and nail deformity. Material A case of subungual exostosis in a female patient is reported. Diagnosis was made performing c...

Why do bisphosphonates work in the treatment of CRPS? A translational pharmacological perspective to solve a conundrum

INTRODUCTION: Bisphosphonates (BPs) have consistently yielded positive results in the treatment of Complex Regional Pain Syndrome (CRPS). However, biochemical and histopathological evidence suggests that osteoclasts, the primary pharmacological target of BPs, is not a key driver...