Istituto di Fisiologia Clinica

Coherent Absorption Reveals Colors Hidden in a Grey Fabry–Pérot Cavity

ABSTRACT Thin dielectric films are known to show distinct colors, depending primarily on the film thickness. In the present article we show that a specialized thin film Fabry–Pérot resonator, that we name conductor–dielectric–conductor (CDC) matched cavity, appears grey when obse...

Insulin resistance in the 21st century: new takes on an old problem—2025 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Insulin Resistance in the 21st Century: New Takes on an Old Problem—2025 Diabetes , Diabetes Care , and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Comparative Prognostic Value of AFP, PIVKA-II, and GPC-3 in Hepatocellular Carcinoma: A Real-World Multicenter Cohort Study

Background/Objectives: The current cornerstone for prognostic hepatocellular carcinoma (HCC) stratification is the Barcelona Clinic Liver Cancer (BCLC) score, which integrates tumor and liver function staging but lacks tumor biology parameters. Serum tumor biomarkers, such as alp...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

Qualitative and Quantitative Differences between GSR and non-GSR Source Particles Revealed by Raman Spectroscopy

Analysis of Gunshot Residue (GSR) is relevant to forensic science by providing a correlation between an individual and a firearms incident. Detection of GSR is usually made by using Scanning Electron Microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (SEM-EDX). Pa...

Systemic Oxy-Inflammatory, Hormonal, and Mood Responses to a Ski Mountaineering Competition: Preliminary Evidence from Military Athletes

The study investigated the systemic responses concerning oxy-inflammation, hormones, and mood after a ski mountaineering competition. Nine experienced military ski mountaineers (age, 32.37 ± 8.90 years; body mass, 59.37 ± 9.58 kg; BMI, 19.85 ± 1.53 kg/m−2) were non-invasively ass...

Estimating the Extent of Missed Opportunities for Osteoporosis Treatment Before Hip Fracture Occurrence

Abstract Hip fractures (HF) are among the most serious consequences of osteoporosis. Many individuals who subsequently sustain a HF may already fulfill recognized criteria for fracture risk assessment, bone mineral density (BMD) evaluation, or anti-osteoporosis treatment before t...

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state and the energy-conserving, ordered (OFF) state. By shifting the ON/OFF equilibriu...

Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS ‐3 MRI

ABSTRACT The patatin‐like phospholipase 3 (PNPLA3) I148M genetic variant is highly associated with steatotic liver disease. In the SURPASS‐3 MRI substudy, tirzepatide significantly reduced liver fat content (LFC) versus insulin degludec in insulin‐naïve patients with type 2 diabe...