Istanbul Eye Hospital

Follicular-Fluid Organic Acid Profiling in Polyendocrine Metabolic Ovarian Syndrome, Poor Responders, and Controls

Follicular-fluid (FF) organic acid concentrations may differ among women with normal ovarian reserve (NOR), polyendocrine metabolic ovarian syndrome (PMOS), and poor ovarian response (POR), reflecting alterations in central carbon and amino-acid-related metabolic pathways. PMOS a...

Real-world outcomes of children with first relapsed acute lymphoblastic leukemia treated according to the ALL-IC REL 2016 guideline in Türkiye

Relapsed acute lymphoblastic leukemia (ALL) remains a major challenge in pediatric oncology, particularly where access to modern immunotherapies is limited. This national multicenter study evaluated real-world outcomes of children with first relapsed ALL treated according to the...

Maternal and Neonatal Outcomes Among Syrian Refugee Women: A Retrospective Study from a Tertiary Hospital in Türkiye

To compare maternal, obstetric, neonatal, and hematological outcomes between Syrian refugee women and Turkish women giving birth at a tertiary hospital in Türkiye. Retrospective cross-sectional study. Sakarya Training and Research Hospital, a tertiary public hospital in Türkiye,...

From Metabolism to Molecular Phenotype: Carbonic Anhydrase IX–Targeted [ 68 Ga]Ga-DPI-4452 PET/CT in Renal Cell Carcinoma: A Prospective Multicenter Comparison with [ 18 F]FDG PET/CT

The objective of this study was to prospectively compare the diagnostic performance, lesion detection capability, and clinical staging impact of [68Ga]Ga-DPI-4452 PET/CT with that of [18F]FDG PET/CT in renal cell carcinoma (RCC) using a multicenter design. Methods: Sixty-eight pa...

Assessing Gamma Index Sensitivity to Selected Linear Accelerator Mechanical Errors Using Various Dosimetric Systems

Background: Volumetric modulated arc therapy (VMAT) for stereotactic body radiotherapy (SBRT) involves highly modulated dose distributions and steep dose gradients, increasing the importance of patient-specific quality assurance (QA). Gamma index analysis is widely used for compa...

Ab Externo Transscleral Removal of Submacular Proliferative Bands in Pediatric Rhegmatogenous Retinal Detachment with PVR: A Surgical Technique Case Series

Purpose: To describe an ab externo surgical technique for submacular band removal in pediatric patients with rhegmatogenous retinal detachment (RRD) complicated by proliferative vitreoretinopathy (PVR). Methods: Ten eyes of 10 pediatric patients diagnosed with RRD and PVR grade C...

Sleep quality in infants with atopic dermatitis: impact of lesion location and disease severity in a retrospective cross-sectional study

Atopic dermatitis (AD) is a common inflammatory skin disorder in infants and is frequently associated with sleep disturbances. Although the relationship between disease severity and sleep quality is well established, the effect of lesion localization on sleep has not been thoroug...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

Thoracic ligamentum flavum ossification causing progressive myelopathy: a case report

Background: Ossified ligamentum flavum (OLF) in the thoracic segments is a rare but significant cause of progressive myelopathy characterized by spinal canal stenosis. While OLF is commonly reported in East Asian populations, it remains under-recognized in other regions, includin...

NBN rs1805794 Polymorphism Increases the Predictive Performance of Machine Learning Models for Multiple Chronic Toxicities in Head and Neck Cancer Survivors Treated with Definitive Radiotherapy ± Chemotherapy

Objective: While advancements in radiotherapy and systemic agents have significantly improved survival rates in head and neck squamous cell carcinoma (HNSCC), managing long-term, treatment-induced toxicities remains a critical clinical challenge. This study aimed to develop a per...

Among Five First-Trimester Complete Blood Count Inflammatory Indices, the Systemic Inflammation Response Index Rises Most Consistently with the Severity of Preterm Birth

Background/Objectives: Complete blood count inflammatory indices are widely studied in obstetrics but rarely compared directly. We compared five first-trimester indices, the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), pan-immune-inflamma...

Crowe severity and femoral stem geometry are associated with lower-limb alignment after total hip arthroplasty for unilateral developmental dysplasia of the hip–related secondary osteoarthritis: valgus alignment trajectories

BACKGROUND: Total hip arthroplasty (THA) for secondary osteoarthritis related to developmental dysplasia of the hip (DDH) restores hip mechanics. We aimed to quantify pre-to-postoperative changes in ipsilateral knee and global lower-limb alignment after unilateral THA to determin...

How reliable is percutaneous transforaminal endoscopic discectomy during the learning curve? A comparison of outcomes with microsurgical discectomy experiences

We aimed to share our early experience with percutaneous transforaminal endoscopic discectomy (PTED) during the initial phase of the learning curve and to compare its clinical and perioperative outcomes with microsurgical discectomy (MD) in selected patients with symptomatic lumb...

Ultrasonographic Evaluation of Superior Cluneal Nerve Entrapment: Methodological Considerations. Comment on Iudicelli et al. The Role of Musculoskeletal Ultrasound in Detecting Superior Cluneal Nerve Entrapment: Biomechanical Insights in Chronic Low Back Pain—A Pilot Study. Diagnostics 2026, 16, 469

Superior cluneal nerve (SCN) entrapment is an underrecognized cause of chronic low back pain, and musculoskeletal ultrasound has recently gained attention as a potential diagnostic tool. In a recent pilot study, an indirect ultrasonographic triad consisting of thoracolumbar fasci...

Evaluation of Bruch’s membrane opening minimum rim width and retinal nerve fiber layer in patients with glaucoma and comparison with normal population

To assess and compare the diagnostic performance of Bruch’s membrane opening–minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness parameters in patients with early-stage glaucoma. This observational cross-sectional study included 60 eyes with primary open-an...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...

The relationshıp between physical examinatıon and radiology in shoulder pseudoparalysis

Abstract Rotator cuff tears, often caused by degeneration, trauma, or repetitive use, can severely affect shoulder function. Pseudoparalysis, characterized by the inability to elevate the arm despite normal passive range of motion, is a challenge in massive tears. This study aime...

Anatomical Outcomes of Traumatic Macular Hole Surgery: Role of OCT Parameters and ILM Flap Techniques

Background: To evaluate anatomical and functional outcomes following pars plana vitrectomy (PPV) for traumatic macular hole (TMH), investigate optical coherence tomography (OCT)-based prognostic factors, and compare outcomes between flap-based and non-flap internal limiting membr...