International University of Health and Welfare

Relationship Between Anterior–Posterior Plantar Reaction Force Distribution and Gait Speed in Post-Stroke Patients

Background: Gait speed is an important indicator of walking ability in post-stroke patients. Although gait speed is associated with anterior–posterior reaction force (AP RF), how AP RF is distributed across the plantar surface and whether this distribution is associated with gait...

Fibroblast-like synoviocytes exacerbate autoimmune arthritis upon psychological stress in an IL-6–dependent manner

Psychological stress affects the immune system and exacerbates autoimmune diseases such as rheumatoid arthritis (RA), but the mechanisms underlying tissue inflammation during remission remain unclear. Here, we show that tube restraint stress exacerbates joint inflammation in a mu...

Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026

Abstract Background Gastric cancer (GC) remains a major global health burden, and early detection is essential for improving patient outcomes. Although GC screening has been widely implemented in East Asian countries with a high disease burden, the optimal screening strategy for...

Advancing Heart Failure Classification Beyond Left Ventricular Ejection Fraction: Unsupervised Machine Learning Insights From the Japanese Nationwide Acute Decompensated Heart Failure Cohort: JROADHF

Background Heart failure (HF) classification based on left ventricular ejection fraction (LVEF) inadequately captures HF heterogeneity, limiting phenotype‐specific therapies. While machine learning (ML) has been applied to HF with preserved ejection fraction, comprehensive approa...

Clinical Study of Bullous Pemphigoid With Oral Mucosal Symptoms After Oral Administration of Dipeptidyl Peptidase‐4 Inhibitors

ABSTRACT Dipeptidyl peptidase‐4 (DPP‐4) inhibitors are widely used for diabetes treatment. However, reports of DPP‐4 inhibitor‐associated bullous pemphigoid (BP) have been increasing. This study examined 12 cases of BP with oral mucosal lesions associated with DPP‐4 inhibitor the...

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1 ‐Dependent Suppression of ROMK

ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous...

Complete genome sequence of Helicobacter pylori strain NY43 harboring bacteriophage KHP30

ABSTRACT The Helicobacter pylori NY43 strain spontaneously releases the bacteriophage (phage) KHP30. Here, we report the complete genome sequence of H. pylori NY43. In addition to the chromosome of H. pylori NY43, we successfully obtained the complete sequence of the episomal pro...

Impact of adjuvant chemotherapy on renal impairment patients following radical nephroureterectomy in upper tract urothelial carcinoma: a multicenter retrospective study

Abstract To evaluate the impact of adjuvant platinum-based chemotherapy (AC) on oncological outcomes in high-risk upper tract urothelial carcinoma (UTUC) patients with postoperative renal impairment following radical nephroureterectomy (RNU). Among 1050 patients who underwent RNU...

Altered Cerebral Perfusion and the Emergence of Schneiderian First-Rank Symptoms Following Modified Electroconvulsive Therapy in Late-Life Depression

Electroconvulsive therapy (ECT) is a well-established treatment for severe or treatment-resistant major depressive disorder and schizophrenia, often leading to rapid symptom improvement. However, ECT can rarely cause adverse psychological effects, including new-onset auditory hal...

New and emerging somatostatin therapies for neuroendocrine tumors: “what is in the pipeline”

INTRODUCTION: Somatostatin receptors (SSTRs) have played a central role in all aspects of the management of neuroendocrine/endocrine neoplasms (NENs). This includes in diagnosis of NENs with the widespread use of radiolabeled SSTR ligands to localize both the primary tumor locati...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Scapular pressure distribution and its association with upper limb function in breast cancer survivors following modified radical mastectomy: a cross-sectional study

Upper limb dysfunction remains a frequent challenge for breast cancer survivors following modified radical mastectomy (MRM) with axillary lymph node dissection (ALND). Although alterations in scapular function may be relevant to postoperative shoulder impairment, scapular-region...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Real-World Longitudinal Treatment Outcomes for Patients with Metastatic Castration-Sensitive Prostate Cancer in Japan

With recent approvals in Japan, identifying optimal first-line therapy for metastatic castration-sensitive prostate cancer (mCSPC) is critical. We evaluated real-world outcomes of androgen-deprivation therapy (ADT) plus androgen receptor signaling inhibitors (ARSIs) as first-line...

Artificial intelligence–driven decision-making after endoscopic resection for early gastric cancer

Early gastric cancer (EGC) is increasingly managed by endoscopic resection (ER); however, lymph node metastasis (LNM), which occurs in approximately 5%-10% of cases, remains the key determinant for recommending additional gastrectomy. Current guideline-based strategies, including...

A pharmacist-led, workplace-based educational intervention informed by behavioral science to influence antimicrobial prescribing in Japan

PURPOSE: Changing antimicrobial prescribing behavior is a key challenge in antimicrobial stewardship (AMS). In postgraduate clinical education, knowledge-based teaching alone is often insufficient to achieve sustained behavior change, highlighting the need for workplace-based edu...

Double vertebral arteries associated with a persistent primitive lateral basilovertebral anastomosis: A rare embryological configuration

Vertebrobasilar vascular anomalies arise from disturbances during the embryological development of the longitudinal neural arteries (LNAs), the proatlantal artery of Padget–Arey (ProA), and the primitive lateral basilovertebral anastomosis (PLBA) [ 1 , 2 ]. We report a rare verte...

d‐Sorbose Promotes Regulatory T‐Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition

ABSTRACT Monosaccharides are fundamental biomolecules involved in various biological processes. Rare sugars, naturally scarce monosaccharide derivatives, exhibit unique physiological effects independent of standard energy metabolism. Among them, d‐sorbose, the C‐3 epimer of d‐fru...

Osteosarcopenia Revisited: From Mechanisms to Management

Abstract Sarcopenia and osteoporosis are characterized by insufficient mass and function of skeletal muscle and bone, and often co-occur in older persons, a condition called osteosarcopenia. Loss of bone and skeletal muscle mass and function is driven by multiple risk factors tha...

P1.196. Short-Term Outcomes of Robot-Assisted Versus Conventional Thoracoscopic Esophagectomy: A Nationwide Inpatient Database Study in Japan

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Although the clinical application of robot-assisted esophagectomy (RE) has increased globally, its advantages over conventional thoracoscopic esophagectomy (TE)...