International Drug Development

Tuning the Photophysical Properties of Corannulene-Based D–A–A Emitters via Steric Isolation and Conformational Flexibility

Abstract We report an asymmetric donor–acceptor–acceptor (D–A–A) strategy to investigate the photophysical properties of corannulene luminogens through the integration of phenylene bridges. Comparison of bridge-free, single-bridged, and double-bridged architectures reveals distin...

Injecting Pills in the Late Fentanyl Era: A Qualitative Investigation of the Procedures Used to Prepare and Inject Prescription Opioids

Background The current study offers updated information on how PWID prepare and inject prescription and illicit drugs. The main objective was to identify potential pathways and reservoirs of infection associated with the tools and techniques used to inject prescription opioids.Me...

Rational drug design for Alzheimer’s disease: from approved therapies to next-generation clinical candidates and AI-guided innovation

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by multifactorial pathology, including amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation, and synaptic dysfunction. Despite extensive research, currently app...