Integrated Chinese Medicine (China)

The relationship between functional prognosis in patients with infection after upper limb trauma: a predictive model based on HbA1c stratification and the mediating role of delayed rehabilitation

OBJECTIVE: To investigate the association between preoperative glycated hemoglobin (HbA1c) and upper limb function (Disabilities of the Arm, Shoulder and Hand [DASH] score) at 6 months post-surgery in patients with fracture-related infection (FRI) after upper limb trauma, and to...

Curcumin Delivery Systems for Inflammatory Skin Application: A Review

Curcumin (CUR) is a low-molecular-weight polyphenolic compound extracted from the rhizomes of the herb Curcuma longa. It exhibits a wide range of pharmacological activities, including anti-inflammatory, antioxidant, hypoglycemic, and antiviral effects. However, its poor solubilit...

Formononetin attenuates skeletal muscle atrophy induced by gastric cancer cachexia

Formononetin (FMN) is a bioactive compound found in traditional Chinese medicinal plants, including red clover and Astragalus membranaceus. FMN has demonstrated anti-inflammatory effects and the promotion of myogenic differentiation. However, its role and precise mechanisms in mu...

Nicotinamide N-methyltransferase in tumor stroma–immune crosstalk: Metabolic–epigenetic mechanisms and translational opportunities

Nicotinamide N -methyltransferase (NNMT) transfers a methyl group from S-adenosylmethionine to nicotinamide, generating 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine and thereby linking nicotinamide disposal, nicotinamide adenine dinucleotide (NAD + ) salvage, and methy...

Triglyceride–glucose body roundness index and risks of incident cardiovascular disease and cardiometabolic multimorbidity: evidence from prospective cohorts in China and England

Cardiovascular disease (CVD) and cardiometabolic multimorbidity (CMM) impose substantial health burdens. The triglyceride–glucose body roundness index (TyG-BRI) integrates metabolic dysfunction reflected by TyG with body-shape information reflected by BRI, but its associations wi...

Modified single-port laparoscopic lateral suspension with bilateral 2-mm micropunctures for moderate-to-severe pelvic organ prolapse: a prospective single-arm feasibility study

Pelvic organ prolapse (POP) affects up to 40% of women over 50 years, with traditional surgical approaches carrying significant morbidity. We evaluated the feasibility and preliminary safety and efficacy of a modified single-port laparoscopic lateral suspension (LLS) technique us...

Remnant cholesterol predicts adverse clinical outcomes in patients with hypertension: a post hoc analysis of the ALLHAT

Background and purpose: Remnant cholesterol (RC) has been proposed to play a role in regulating the residual cardiovascular risk in individuals with atherosclerotic cardiovascular disease (ASCVD), yet the underlying mechanisms remain elusive. This study aimed to investigate the r...

Dose–response associations of the composite dietary antioxidant index and related nutrients with prevalent chronic kidney disease: NHANES 2003–2018

Oxidative stress is implicated in kidney dysfunction, but population-based evidence linking dietary antioxidant profiles to prevalent chronic kidney disease (CKD) remains limited. We examined associations of the composite dietary antioxidant index (CDAI) and selected antioxidant-...

Prevalence and occupational risk factors of dry eye symptoms among Chinese healthcare workers

Healthcare workers (HCWs) in China are at a high risk of self-reported dry eye symptoms due to occupational exposures, yet population-based epidemiological data on this issue among Chinese HCWs remain scarce. This multicenter cross-sectional study aimed to quantify the prevalence...

A review of power conversion and energy management technologies in rheumatoid arthritis diagnostic equipment

Purpose This study aims to investigate electrical energy management challenges across rheumatoid arthritis (RA) diagnostic devices, addressing a critical gap between large high-resolution imaging equipment and portable microsystems. The research seeks new insights into key power...

Exploring key genes associated with metabolic cell death in ischemic stroke: a comprehensive analysis of single-cell, bulk transcriptome, and experimental validation

Metabolic cell death and ischemic stroke (IS) may be closely correlated. In this study, we identified key metabolic cell death-related genes (MCD-RGs) in IS, which may provide insight into ischemic injury and candidate targets for future therapeutic exploration. GSE163654, GSE306...

Perfluorodecanoic acid (PFDA) exposure, through stabilizing HIF-1α to induce VEGF/VEGFR2 autocrine signaling, promotes colorectal cancer cell proliferation

Perfluorodecanoic acid (PFDA) is a persistent organic pollutant widely present in the environment and resistant todegradation. In recent years, due to its extensive use in industrial production and consumer products, PFDA continuously accumulates in organisms and has become a glo...

Internal Experiences of Self-Stigma Among Patients with Schizophrenia Based on the Common-Sense Model: A Qualitative Study

Patients with schizophrenia endure not only severe symptom burden but also prolonged exposure to public stigma, with self-stigma emerging as a critical psychological barrier to recovery. Previous studies have primarily examined the association between illness perception and self-...

Weight regain following discontinuation of glucagon-like peptide-1 receptor agonists in adults who are overweight or obese: a systematic review and meta-analysis

Objective This study aims to explore the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on weight changes and the occurrence of adverse reactions in overweight or obese adults after drug withdrawal. Methods Computerized searches were conducted in evidence-based d...

Thermogenic adipose tissue as a therapeutic target: from human heterogeneity to pharmacological translation

Thermogenic adipose tissue, including classical brown adipose tissue (BAT) and inducible beige adipocytes, has re-emerged as a promising therapeutic target in the obesity field. Because BAT can convert chemical energy into heat while also playing a role in regulating systemic glu...

Glyoxal induces arterial injury through the inactivation of receptors and signaling pathways

Glyoxal exposure is associated with a spectrum of adverse health outcomes, including arterial injury. While existing evidence confirms that glyoxal targets oxidative stress and the mitogen-activated protein kinase pathway, the precise underlying mechanism of glyoxal-induced arter...

Integrative Traditional Chinese Medicine Approaches for Plasma Cell Mastitis: Clinical Efficacy and Mechanistic Insights—A Narrative Review

Background Plasma cell mastitis (PCM) is a chronic nonlactational inflammatory breast disease characterized by recurrent inflammation, abscesses, sinus tracts, fibrosis, and high recurrence risk. Current treatments mainly target symptoms and complications but may not fully addres...

Vitamin D in spine disorders: mechanisms, clinical evidence, and translational gaps—a narrative review

Vitamin D has been increasingly implicated in the pathophysiology of spine disorders, yet its clinical utility remains uncertain. Across a broad spectrum of conditions, including intervertebral disc degeneration, chronic low back pain, lumbar spinal stenosis, spinal deformities,...

Comparative Efficacy of Body Acupuncture, Electroacupuncture, and Auricular Acupuncture in Stroke Rehabilitation

OBJECTIVE: To compare the efficacy of body acupuncture, electroacupuncture, and auricular acupuncture on motor, functional, and neurological recovery after stroke. DESIGN: Systematic review and meta-analysis of randomized controlled trials. Eligible studies enrolled adult stroke...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...