Instituto Nacional de Neurología y Neurocirugía

Identification of SOD1 Gene Variants in Mexican Patients with Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing, fatal neurodegenerative disorder that selectively affects motor neurons. Clinical manifestations include progressive muscle weakness, amyotrophy, fasciculations, dysphagia, and fatal respiratory failure. The median sur...

A Structured Framework for Translation of the ACNS Standardized Critical Care EEG Terminology Into Spanish

Purpose: The American Clinical Neurophysiology Society (ACNS) Critical Care EEG Terminology provides standardized language for describing electroencephalographic (EEG) patterns in critically ill patients but has not been formally translated into Spanish. We aimed to develop a con...

Human claustrum neurons encode uncertainty and prediction errors during aversive learning

Flexible behavior depends on continuous updating of internal models, yet the neural circuits coordinating this process remain poorly understood. The claustrum, which is reciprocally connected to nearly the entire neocortex, is uniquely positioned to influence cortical processing....

Comparative Efficacy of Embolic Agents for Single-Session Meningeal Artery Embolization and Surgical Evacuation: Evaluating Liquids, Particles, and Adjunct Coils

BACKGROUND AND OBJECTIVES: Single-session middle meningeal artery embolization (MMAE) combined with surgical evacuation is an emerging strategy for management of patients with chronic subdural hematoma (cSDH). However, comparative outcome data based on embolic material selection...

Jugulotympanic paraganglioma, preoperative embolization, and transmastoid retrolabyrinthine approach: Two-dimensional operative video

Background: Jugulotympanic paraganglioma (JTP), also known as glomus jugulare tumor, is a neuroendocrine neoplasm. Although it represents <0.5% of head-and-neck tumors, it demonstrates significant local aggressiveness due to its tendency to infiltrate bone, vascular structures, a...

The Influence of Behavioral Intention on the Entrepreneurial Passion and Organizational Commitment of Women Entrepreneurs: A Qualitative Study

In Mexico, women entrepreneurs represent a significant portion of the population that contributes economically to the country. Few studies describe the challenges they face in creating and maintaining businesses, such as access to resources and the motivations that influence thei...

Sex Differences in Oxidative Stress and Depression-Like Behavior Following Chronic Lead Exposure from Pregnancy to Adulthood

Abstract Lead (Pb) is a neurotoxic heavy metal that crosses the placental barrier and may affect fetal development. However, the effects of chronic developmental Pb exposure on oxidative stress, stress-related endocrine responses, and depression-like behavior, particularly regard...