Instituto de Medicina Tropical

Identifying Cardiac Autoantibody Biomarkers that Predict the Severity of Chagas Cardiomyopathy

Chagas cardiomyopathy (ChCM) affects up to 30% of patients with chronic Chagas disease and lacks reliable biomarkers for severity and conduction abnormalities. We profiled cardiac autoantibodies using 2-dimensional gel electrophoresis and mass spectrometry, followed by enzyme-lin...

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-sp...

Temporal stability and characteristics of breeding sites for Anopheles coluzzii, a major malaria vector on the island of São Tomé

Abstract Background Characterization of mosquito breeding sites is important for efficient, targeted vector control. Such information is lacking for the tropical African island of São Tomé where malaria cases are low but persistent and larvicidal control is regularly utilized. He...

Diagnostic strategies for the detection of Sarcocystis spp. and Toxoplasma gondii in bovine hearts from São Paulo, Brazil

Abstract Foodborne parasitic zoonoses such as toxoplasmosis and sarcocystosis represent a public health challenge and an economic loss in the beef production chain, a sector in which Brazil lacks a specific laboratory monitoring program. This study aimed to detect Sarcocystis spp...

The value of mortality data to advance learning and decision-making dynamics in Mozambique’s health system

Abstract Introduction There is a lack of evidence on whether and how health systems stakeholders in Mozambique learn from routine health data. Despite the recurring claim by the stakeholders themselves that data in general should be the centre of informed public health policy, it...