Instituto de Investigación Sanitaria La Fe

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

Percentiles for crying, regurgitation, stool consistency, and CoMiSSTM in presumed healthy infants

Parents frequently consult health care professionals because of infant regurgitation, crying and stool consistency. The Cow’s Milk-related Symptom Score (CoMiSS TM ) is an awareness tool for cow’s milk allergy. We aimed to characterize the distribution of CoMiSS items in presumed...

Circulating plasma microRNAs as potential non-invasive biomarkers in infertile women with adenomyosis: an observational study

Despite advancements in imaging techniques, the non-invasive diagnosis of adenomyosis remains particularly challenging due to the overlap of imaging features with other uterine diseases, and the lack of consistent correlation with clinical presentation, with histological confirma...