Instituto de Investigación Sanitaria Aragón

Dissecting Binary and Ternary Iminoboronate Assemblies: A Calorimetric Study of Thermodynamics, Kinetics, and Allosteric Effects

Abstract Dynamic covalent assemblies derived from ortho-boronoaldehydes, including iminoboronates and boronate esters, are key structural motifs in adaptive materials, chemical sensors, and reversible bioconjugation strategies. Herein, we report a label-free assay based on isothe...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Glucose and Oxygen Availability Shape Growth and Architecture of Tumor Spheroids in a Microfluidic 3D Model

Glucose and oxygen availability are fundamental drivers of tumor progression, deeply influencing cancer cell proliferation, metabolism, and spatial organization. In this study, we present a simplified microfluidic-based 3D model of tumorigenesis that allows for controlled and dyn...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Effects of specialized pro-resolving mediators and telerehabilitation on fatigue, dyspnea, and quality of life in post‑COVID‑19 condition: the ARACOV-02 randomized controlled trial

Post‑COVID‑19 Condition (PCC) is characterized by persistent multisystem symptoms, with fatigue and dyspnea among the most disabling. Specialized pro‑resolving mediators (SPMs) may modulate chronic inflammation, while telerehabilitation has emerged as an accessible therapeutic st...

Efectividad de las intervenciones en las escuelas para la prevención y reducción de la obesidad y el sobrepeso infantil: una revisión sistemática y un metaanálisis

Resumen Objetivo Sintetizar la evidencia sobre la efectividad de las estrategias de los programas escolares destinados a la disminución de la prevalencia de la obesidad y el sobrepeso infantil. Diseño Revisión sistemática y metaanálisis siguiendo las recomendaciones PRISMA. Fuent...

Adaptive response to serine and glycine deprivation enhances the stemness potential of pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) develops within a nutrient-poor microenvironment, where pancreatic cancer stem cells (PaCSCs) can persist despite limited oxygen and nutrient availability. This resilience partially relies on mitochondrial metabolic flexibility. Serine and...

Eye-Tracking Assessment of Visual, Oculomotor, and Pupillary Biomarkers During Reading in Parkinson’s Disease

Parkinson’s disease (PD) is associated with visual, cognitive, and oculomotor alterations that may impair reading, highlighting the potential of eye tracking to objectively characterise these changes during a task. An observational study included 46 patients with PD, classified a...

From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME

Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) are leading causes of visual impairment and require long-term intravitreal anti-vascular endothelial growth factor (VEGF) therapy. However, treatment burden and suboptimal real-world outcomes rem...

Does size matter? A secondary analysis of the effect of region-of-interest size on muscle echotexture features of the gastrocnemius medialis in stroke

The analysis of muscle echotexture using ultrasound imaging is attracting increasing interest for assessing muscle tissue across different health conditions. However, variability in the size of the region of interest (ROI) can affect echotexture assessment. This study examines ho...

Liver-directed gene therapy results in amelioration of progressive familial intrahepatic cholestasis type 2 in mice

Background: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare disease affecting the ABCB11 gene, encoding the bile salt export pump (BSEP). BSEP dysfunction impairs bile acid (BA) secretion, causing hepatic damage and leading to pruritus, cholestasis, hepatom...

Eating Behavior Latent Profiles and Their Associations With Body Composition in Early Childhood: The CORALS Cohort

ABSTRACT Objective This study aimed to identify sex‐specific eating behavior profiles and assess the associations between eating behaviors subscales and profiles and body composition indices in Spanish preschoolers from the CORALS cohort. Methods We conducted a cross‐sectional an...

LPA genetic variation is associated with type 2 diabetes after adjustment for lipoprotein(a) concentration: results of the Aragon Workers’ health study

Abstract Background Epidemiological and Mendelian randomization studies have reported an inverse relationship between lipoprotein(a) [Lp(a)] concentration and type 2 diabetes (T2D), although findings have not been uniform across studies. We hypothesized that genetic variation at...