Instituto de Investigación Biosanitaria de Granada

Early-life risk factors and cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis

Early-life metabolic, endocrine, and nutritional exposures may be associated with later cardiometabolic health. We aimed to identify early-life risk factors occurring during preconception, pregnancy and birth, and infancy up to 2 years that are associated with glucose intolerance...

Feasibility of a school-based cardiopulmonary resuscitation educational programme incorporating microlearning and gamification in primary school children: a prospective observational study

Abstract Cardiorespiratory arrest (CRA) is a priority public health problem whose survival depends largely on the early action of the community as the first link in the life-saving systems (chain of survival). In this context, international organisations such as the European Resu...

Real-world safety and clinical outcomes of cluster subcutaneous immunotherapy with olive pollen extracts, with or without grass pollen, in patients with allergic rhinoconjunctivitis and/or asthma

Abstract Background Allergen immunotherapy (AIT) is the only treatment capable of modifying the natural course of IgE-mediated allergic diseases induced by aeroallergens. Cluster schedules for subcutaneous AIT (SCIT) with hypoallergenic depot extracts enable faster dose escalatio...

Neuromyelitis optica spectrum disorder associated with Kabuki syndrome: First reported case and immunopathogenic considerations

Kabuki syndrome, caused by KMT2D or KDM6A mutations, is a multisystem disorder with immune dysregulation. Its association with aquaporin-4 (AQP4) antibody–positive neuromyelitis optica spectrum disorder has not been reported. A 17-year-old male with autoimmune hypothyroidism pres...

Geographic Variation and Core Signatures of the Root Canal Microbiome: A Cross‐Country Comparative Study

AIM: Root canal infections harbour complex microbial communities that may vary across geographic populations. This study aimed to compare the root canal microbiome across Spain, Sweden, and the USA, identifying key microbial taxa, compositional and functional differences, and coh...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Community assembly on inland cliffs is context‐dependent

Abstract Under harsh environmental conditions, community assembly processes are expected to drive pronounced functional convergence, with communities dominated by stress‐tolerant species. Integrating local communities with their regional species pools enables evaluating environme...

Impact of Chronic Spontaneous Urticaria on Major Life-Changing Decisions: An Exploratory Cross-Sectional Study

Background: Chronic Spontaneous Urticaria (CSU) profoundly impairs health-related quality of life due to intense pruritus and unpredictable flares. However, its specific influence on patients’ major life-changing decisions (MLCD)—such as career choices, family planning, and perso...

Endocannabinoid system dysregulation in oral diseases: mechanistic insights and therapeutic modulation

Abstract Background Chronic inflammatory and neoplastic diseases of the oral cavity, including periodontitis, oral lichen planus (OLP), oral squamous cell carcinoma (OSCC), and oral mucositis, represent a significant global health burden. Current therapeutic strategies face limit...

Nasoalveolar Molding and Feeding in Infants with Cleft Lip and Palate: An Exploratory Study of Parents’ and Caregivers’ Perceived Experiences

Background/Objectives: Patients with cleft lip and palate (CLP) typically experience feeding difficulties due to an abnormal communication between the oral and nasal cavities, and novel therapies such as palate tissue engineering and nasoalveolar molding (NAM) are in need to impr...

Comparative analysis of blood inflammatory profile and intestinal microbiota in late-fetal growth restriction vs. normal pregnancy

To determine the association of blood inflammatory biomarkers and intestinal microbiota composition in women with late-onset fetal growth restriction. Fetal growth restriction (FGR) is a pathological condition in which fetus fails to achieve its genetically determined growth pote...

Disease progression in hidradenitis suppurativa: A multidimensional framework

Abstract Hidradenitis suppurativa (HS) is increasingly recognized as a progressive inflammatory disease in which recurrent follicular inflammation, tunnel formation and systemic inflammation drive cumulative, largely irreversible tissue damage, quality‐of‐life impairment and card...

Sorption of Pharmaceuticals onto Polyethylene Terephthalate and Medium-Density Polyethylene: Influence of Plastic Polymer Type and Water Medium

The growing accumulation of microplastics in marine ecosystems, coupled with the presence of emerging contaminants such as pharmaceuticals, represents an environmental problem that has received little attention to date. The present study evaluates the potential of microplastics t...

Whole-genome sequencing of Reed-Sternberg cells identifies outcome determinants in Hodgkin lymphoma

Abstract Classical Hodgkin lymphoma (cHL) is a B-cell-derived malignancy characterized by rare Hodgkin and Reed–Sternberg (HRS) cells within an extensive inflammatory microenvironment. Although most patients achieve durable remission with first-line therapy, a subset relapse or e...

A RAC1 SUMOylation switch governs breast cancer metastasis

Despite the major advances in breast cancer management over the past few decades, metastatic breast cancer continues to be a major concern and the main cause of mortality associated with this disease. The Rho GTPase RAC1 has been implicated in breast cancer aggressiveness, yet th...

Plasma proteomes of obesity and allometric body shapes in the EPIC cohort

Abstract General obesity (high body mass index, BMI) affects circulating proteins. Obesity-related outcomes, however, differ by body shape but waist and hip circumferences cannot distinguish abdominal from general obesity. We therefore used the allometric body shape index (ABSI),...

Update on Perioperative Prevention of Cardiac Surgery-Associated Acute Kidney Injury

Cardiac surgery-associated acute kidney injury (CS-AKI) increases short- and long-term mortality, progression to chronic kidney disease (CKD), and healthcare costs. Its pathogenesis is multifactorial—combining renal hypoperfusion, impaired oxygen delivery, hemodilution, inflammat...

Bridging Clinical Practice and Research: Semi-Automated Extraction and Analysis of Parkinson’s Imaging Data from Real-World Setting

Neuroimaging is essential for understanding Parkinson’s disease (PD) and other atypical parkinsonian syndromes. However, the scarcity of large-scale, accurately annotated datasets presents a critical challenge for training robust machine learning models and advancing translationa...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

Malnutrition Severity, Morphofunctional Assessment, and Survival in Patients with Lung Cancer: A Multicentre Prospective Cohort Study

PURPOSE: Malnutrition is common in lung cancer and may contribute to impaired functional status and poor survival. This study evaluated the association between GLIM-defined malnutrition, morphofunctional nutritional parameters, and one-year mortality in patients with lung cancer....