Instituto de Biomedicina de Sevilla

Cord blood DNA methylation differences associated with gestational diabetes and partial consistency with maternal methylation patterns

Gestational diabetes mellitus (GDM) increases offspring cardiometabolic risk, potentially through intrauterine epigenetic programming. We aimed to characterize GDM-associated DNA methylation differences in cord blood, evaluate their consistency with previously identified maternal...

Orthorexia Nervosa Risk and Psychological Correlates in Higher-Education Dance Students

BACKGROUND: Orthorexia nervosa has been increasingly examined in performance-oriented populations; however, evidence in higher-education dance students remains limited, particularly across multiple dance disciplines and with integrated psychological assessment. OBJECTIVE: To exam...

Redefining liver health: a multidimensional approach to preventing metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction–associated steatohepatitis (MASH) is a rapidly escalating global health challenge driven by complex interactions among metabolic regulation, nutrition, immune signalling, gut microbiota, and environmental exposures. Current disease-centric frameworks priorit...

Lupin protein hydrolysate ameliorates MASLD: identification and in silico validation of peptides targeting the KEAP1–NRF2 axis

The rising prevalence of obesity and its comorbidities, including metabolic dysfunction–associated steatotic liver disease (MASLD), requires novel preventive strategies, such as functional foods. Lupinus angustifolius protein hydrolysates (LPH) exhibits potent immunomodulatory an...

Elucidating the mechanism underlying incomplete immune recovery in people living with HIV through CD4⁺ and CD8⁺ T cell multi-omics

A subset of people living with HIV (PLHIV), known as immunological non-responders (INR), fails to achieve adequate CD4⁺ T cell recovery despite viral suppression with antiretroviral therapy (ART). These individuals face an increased risk of adverse clinical outcomes. This study a...

Glycemic Patterns Assessed by Continuous Glucose Monitoring in People with Type 2 Diabetes Treated with Insulin Glargine 100 U/mL in Primary Care: The GPDetect Study

Hypoglycemia is a common complication in people with type 2 diabetes mellitus (T2DM) treated with basal insulin, yet its true prevalence in real-world primary care remains underexplored. This study used blinded continuous glucose monitoring (CGM) to assess glycemic patterns in pa...