Institution
Institute on Aging
Recent research
- BiologyOpen access
Epigenetic aging in people with HIV across the life course: a systematic review and meta-analysis
Abstract Epigenetic aging algorithms are emerging tools for understanding the biological effects of human immunodeficiency virus (HIV). A growing body of literature has applied DNA methylation-based epigenetic clocks in people living with HIV (PWH) across the life course, examini...
- BiologyOpen access
Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...
- AI & ComputingOpen access
Objectives: This study assessed changes in the visibility of the National Health Information Portal (NHIP), operated by the Korea Disease Control and Prevention Agency, across conventional search portals and generative artificial intelligence (AI) platforms. Methods: We analyzed...
- BiologyOpen access
Sex-specific biological aging clocks across organs and omics
Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer’s disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex in...
- Health & MedicineOpen access
Public policies governing U.S. nursing homes emphasize resident rights, autonomy, and person-centered care, yet translating these principles into everyday practice remains challenging – particularly for residents living with dementia whose preferences involve perceived risk. Regu...
- BiologyOpen access
Robust inference and correlates from genetic associations with personality
Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...
- BiologyOpen access
Background: Hearing loss is experienced by two-thirds of hospitalized older adults and is associated with poor access to healthcare and negative health outcomes. Personal hearing amplifiers (PHAs) are evidence-based assistive devices provided in many hospitals to improve accessib...
- Health & MedicineOpen access
Health-related quality of life reflects individuals’ perceptions of how a health condition affects their physical, psychological, and social functioning. Amid increasing pressures on primary care systems, people living with dementia are presenting more frequently to hospital sett...