Institute of Post Graduate Medical Education and Research

Antifungal therapy for newborn infants with invasive fungal infection

RATIONALE: A variety of antifungal drugs, drug preparations and drug combinations are available to treat newborn infants with suspected or confirmed invasive fungal infection. There is a need to assess their relative merits. OBJECTIVES: To evaluate the benefits and harms of treat...

Sentinel serosurvey for Mpox virus infection among key populations in India: Evidence of sporadic past exposure beyond travel-related cases

Background and objectives Mpox, declared a public health emergency of international concern by WHO, has demonstrated sporadic transmission globally. While India reported 66 confirmed cases predominantly linked to international travel, the possibility of silent community circulati...

Low‐Level Laser Therapy Versus Mirror Therapy for Post‐Stroke Complex Regional Pain Syndrome Type I: A Randomised Controlled Trial

ABSTRACT Background Complex Regional Pain Syndrome type 1 (CRPS‐I) following stroke has been managed by several conservative methods to date. But the efficacy of Low‐level laser therapy (LLLT) was never compared with the Mirror therapy (MT) in these cases. Aim and Objective To co...

Regulatory T cells as drivers of CNS remyelination: neuro-immune cross-talk and comparative insights from mammalian and zebrafish models

Demyelination of the Central Nervous System (CNS) is a pathological process that causes the destruction of the myelin sheath, the insulating cover that protects the nerve fibres. This serves as one of the major attributes of numerous neurological disorders, such as Multiple Scler...

COVID-19 lockdown and coverage of maternal health and nutrition care in rural West Bengal, India: a single interrupted time-series analysis

Abstract While COVID-19 lockdowns globally disrupted healthcare, the extent of changes in India’s maternal health and nutrition services coverage in rural settings requires further empirical investigation. Utilizing data from 57,371 pregnancies recorded between January 2012 and D...

Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD

Background Hepatocyte ballooning is a defining histological marker of progressive steatohepatitis, but its molecular basis remains poorly defined. Objective To identify a molecular signature and mechanistic trajectory underlying hepatocyte ballooning across the MASLD-to-hepatocel...

A comparative study of the effectiveness of cooled versus room temperature lignocaine gel for relieving pain during optical internal urethrotomy

Introduction: Optical Internal urethrotomy (OIU) is conventionally performed under regional anaesthesia. Various studies have shown that it can be done under local anaesthesia. However, regional anaesthesia provides better pain control than local anaesthesia. Cold lignocaine gel...

“A comparison of pre-operative urine culture with intra-operative stone culture and its association with post-procedural sepsis: a prospective observational study”

<title>Abstract</title> <bold>Background and Aim:</bold> Urosepsis is a dreaded complication following endourological procedures. Urinary calculi are known to harbour bacteria that may be released into the circulation during fragmentation, potentially leading to urosepsis. Thus,...

Nucleotide Driven Hierarchical Self‐Assembly of Covalent Organic Framework and Gold Nanostar for Molecular Diagnosis of Turner Syndrome

ABSTRACT Turner Syndrome (TS), a rare chromosomal disorder, cause significant phenotypical changes like growth failure and primary ovarian insufficiency. Chromosomal karyotyping, the preferred diagnostic method till date, resulting in delayed diagnosis that precludes early interv...