Institute of Mountain Hazards and Environment

Systematic Screening of Depression-Related Neurotoxicity Across 26 Bisphenols Reveals an ESR1–CREB1–GRIN2B-Associated Mechanism

Bisphenols (BPs) are widespread environmental endocrine disruptors, but their potential depression-related neurotoxicity has not been systematically assessed. Here, we combined machine learning (ML), network toxicology, molecular docking, and in vivo experiments to screen 26 bisp...

An SPCL-Stacking ensemble learning framework for landslide susceptibility assessment

Abstract Background Machine learning has been increasingly applied to data driven landslide susceptibility assessment. However, false negative label noise introduced during negative sample selection and the limited predictive capability of single models remain unresolved issues....

Topographic aspect shapes temperature lapse rates and land–atmosphere energy exchange in global mountains

Mountain regions exhibit complex thermal gradients that regulate land–atmosphere energy exchange, yet the global influence of topographic aspect on temperature lapse rates (LRT) remains poorly characterized. Here, we investigate global LRT patterns and their sensitivity to topogr...