Institute of Medical Sciences

Knowledge, Attitude, and Perception toward Black-Box and Scheduled Drug Warnings Among Undergraduate Medical Students: A Cross-Sectional Study in a Tertiary Medical Institution in Andhra Pradesh, India

AbstratctIntroduction: Black Box Warnings (BBW) issued by the U.S. Food and Drug Administration (FDA) identify serious or life-threatening risks associated with certain medicines. In India, scheduled-drug warnings issued under the regulatory framework of the Central Drugs Standar...

Assessing impact of climate change on medicinal plants through yield decline, metabolite variability and range shifts

Abstract Climate change is one of the most grave environmental problems of the 21st century faced by organisms on Earth. It adversely impacts organisms including medicinal plants which contribute greatly to the healthcare system. It affects growth, chemistry and distribution of m...

Sociodemographic Predictors of Neurological Outcomes and Quality of Life in Acute Stroke Patients: A Hospital-based Prospective Study from South India

Abstract Introduction: Stroke remains a major cause of death, disability, and reduced quality of life worldwide, with a disproportionate burden in low- and middle-income countries. In India, inequalities in income, occupation, education, and access to preventive care may influenc...

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

The molecular mechanisms governing mRNA accumulation during oocyte growth, essential for developmental competence, remain poorly understood. This study investigates the role of Matrin-3 (MATR3), a highly expressed RNA-binding protein in growing oocytes (GOs), using oocyte-specifi...

Dosimetric Comparison of One-, Two-, Three-, and Four-Arc Volumetric Modulated Arc Therapy Plans in Cervical Carcinoma: Evaluation of Plan Quality, Organ-at-Risk Sparing, and Treatment Efficiency

BackgroundVolumetric modulated arc therapy (VMAT) has transformed the delivery of pelvic radiotherapy in cervical carcinoma, enabling precise dose conformity around critical organs while maintaining efficient treatment delivery.One important planning consideration that remains in...

Smartphone addiction, bedtime procrastination, and sleep quality among medical students: an observational study

Medical students, owing to academic pressure and extensive digital device use, are particularly vulnerable to poor sleep quality. As smartphone addiction and bedtime procrastination are increasingly recognized as important behavioral factors influencing sleep, evaluating their in...

Bridging the Frozen Section Gap: Diagnostic Utility of Intraoperative Cytology in Ovarian Tumours From a Rural Tertiary Care Centre in South India

BACKGROUND: Ovarian neoplasms are a significant cause of morbidity among women, particularly in resource-limited rural settings where access to advanced diagnostic facilities is often restricted. Intraoperative cytology provides a rapid and cost-effective diagnostic adjunct that...

Efficacy of a novel polylactic acid/nanoclay (NK-75) biodegradable composite scaffold in healing critical-size bone defects: an experimental study in a rabbit ulnar model

Abstract Background Critical-size bone defects remain a formidable challenge in orthopaedic surgery. Biodegradable polymer scaffolds represent a promising alternative to autologous bone grafting, but conventional polylactic acid (PLA) scaffolds exhibit limited osteoconductivity a...

Disulfiram-Induced Catatonia Following a Disulfiram–Alcohol Reaction: A Case Report

Disulfiram is commonly used in the management of alcohol dependence. Although generally safe, it may rarely lead to neuropsychiatric adverse effects such as catatonia. We report a case of a 32-year-old male with alcohol dependence who developed acute catatonic symptoms following...

SpineXR-VQA: A Clinically-Validated Visual Question Answering Dataset for Spine X-Rays

Recent progress in Medical Visual Question Answering (VQA) has significantly aided clinical decision-making across various domains such as pneumonia, oncology, and neurology. However, spinal and musculoskeletal ailments remain critically underexplored. The development of reliable...

Prevalence of Asymptomatic Pyuria in Patients with Type 2 Diabetes Mellitus and Its Association with Glycemia

Abstract Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of urinary tract infections, including asymptomatic forms like asymptomatic bacteriuria or asymptomatic pyuria (ASP). However, the association between ASP (defined as elevated urinary leukoc...

Neurobehavioral Evaluation of Renin-Angiotensin System Modulators in an MPTP-Induced Model of Parkinson’s Disease in Swiss Albino Mice

BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor deficits. Emerging evidence suggests a role of the renin-angiotensin system (RAS) in neurodegeneration, making it a potential therapeutic target. AIM: To evaluate...

Symptomatic Sclerosing Pneumocytoma of Lung: A Diagnostic Challenge with Diverse Morphological Patterns.

Background & Objective: Sclerosing pneumocytoma (SP), formerly termed sclerosing hemangioma, is a rare benign lung neoplasm often detected incidentally. Its histological diversity and dual cell population frequently complicate diagnosis, particularly in small biopsies. Case Prese...

Integrative transcriptomic analysis identifies shared coding and non-coding biomarkers in tongue squamous cell carcinoma across diverse populations

Abstract Background Tongue cancer, a prevalent subtype of oral malignancy, remains a significant global health burden with high morbidity and mortality, particularly in developing countries. Understanding its molecular landscape is crucial for developing targeted diagnostics and...

Tele-Optometry and Mobile Eye Care Units: A Rural Vision Care Model for India

India accounts for about 20% of the world’s visually impaired population. Rural and underserved populations are disproportionately affected by avoidable causes of blindness such as uncorrected refractive errors, cataracts, diabetic retinopathy, and glaucoma. Traditional facility-...

A narrative review of Zika virus cardiotropism and atrial fibrillation from pathogenesis and diagnostic challenges to inflammation aware management

Systemic inflammation is a key driver of atrial fibrillation (AF), but the mechanisms linking specific viral triggers to arrhythmogenesis are not fully understood. Zika virus (ZIKV) infection, which can induce a significant inflammatory response, provides a compelling clinical mo...

The demand-side gap: integrating AWaRe-based antibiotic stewardship into medical education in Pakistan

To the EditorI read with interest the recent analysis by Abdullah et al. titled ‘Surge of branded generics and antimicrobial resistance: analyzing the antibiotic market dynamics in Pakistan through...

Quantifying the social net: a nomogram to predict baseline quality of life at clinical entry for head and neck cancer

Abstract Background Quality of life (QoL) and psychological distress are critical yet under-evaluated dimensions of head and neck squamous cell carcinoma (HNSCC) management. While clinical staging is a primary determinant of survival, the influence of the socio-economic “safety n...

When Treatment Leaves a Mark: Trifluoperazine-associated Hyperpigmentation in a Case Series

Abstract Drug-induced skin hyperpigmentation is a known but often overlooked side effect of phenothiazine antipsychotics. While chlorpromazine is commonly implicated, reports involving trifluoperazine are limited. Because psychiatric treatment is often long term and involves mult...

Comparative Evaluation of the Efficacy of C-MAC™, McGrath MAC™ Videolaryngoscopes, and the Direct Miller Laryngoscope for Neonatal Intubation under General Anesthesia

BACKGROUND: Neonatal endotracheal intubation remains technically challenging due to small airway dimensions and limited glottic visualization. Identifying the most effective device and technique to secure the airway is crucial. Video laryngoscopes (VLs) have been introduced to en...