Institute of Infection and Immunity

High-Risk Clones of Carbapenem-Resistant Pseudomonas aeruginosa in India: Genome and Traits

Pseudomonas aeruginosa is a notorious opportunistic pathogen constituting a major cause of health care-associated infections worldwide. Intrinsic resistance to multiple antibiotics, with acquired resistance mechanisms and hypervirulence make it a critical target for genomic inves...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Knowledge, attitude, and practice of antifungal resistance and stewardship among pharmacy students in Zambia: a cross-sectional study to inform antifungal stewardship programs

Background Antifungal resistance (AFR) is a growing global health threat, particularly in low- and middle-income countries such as Zambia, where antifungals are often accessed without prescription. Antifungal stewardship (AFS) programs aim to optimise antifungal use, yet limited...

Mucin promotes Psl production and surface exploration in Pseudomonas aeruginosa

ABSTRACT In chronic, recalcitrant infections, Pseudomonas aeruginosa forms biofilm aggregates that are encapsulated in a protective extracellular matrix made of exopolysaccharides, extracellular DNA, and matrix proteins. Biofilm formation is a major cause of antibiotic clearance...

Converging pathomechanisms link SARS-CoV-2 infection with major neurodegenerative diseases

Neurological complications are among typical clinical manifestations, both during the acute phase of SARS-CoV-2 infection and long-term post-acute COVID-19 sequelae, i.e., Long COVID. A growing body of evidence connects SARS-CoV-2 infection to systemic inflammation, peripheral im...

Pseudomonas aeruginosa mgtC gene is under the control of PhoP and CbrAB regulators, and its expression can be visualized in macrophages

ABSTRACT The MgtC virulence factor is important during the intramacrophage stage in both classical intracellular pathogens, such as Salmonella Typhimurium, and in extracellular bacteria that transiently encounter intracellular environments during infection, such as Pseudomonas ae...

Innate immune recognition of Debaryomyces hansenii requires Dectin-1-Card9 signaling

ABSTRACT Innate immune signaling plays a key role in host response to infection, yet the pattern recognition receptors that detect non-model gut-associated yeasts remain poorly defined. Here, we investigated macrophage sensing of Debaryomyces hansenii , a food-derived yeast that...