Institute for Integrative and Experimental Genomics

Endothelial neo-antigen expression initiates CD8⁺ T cell–driven CNS vasculitis amplified by peripheral immune challenge

Primary central nervous system (CNS) vasculitis is a rare and devastating inflammatory cerebrovascular disease for which pathogenic mechanisms remain poorly defined, largely due to limited access to human tissue and the absence of validated experimental models. Here, we present a...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

The application value of artificial intelligence in medical imaging: foundations, progress, and challenges

Abstract Artificial intelligence (AI) is rapidly transforming medical imaging, reshaping the field as it does everyday life. As imaging data grow in complexity and clinical workloads continue to rise, AI has become increasingly essential for improving diagnostic efficiency and pr...

LPV Updates for Sequentially Linearized Moving Horizon Estimation of Nonlinear Systems

ABSTRACT Moving horizon estimation (MHE) provides high‐precision state estimation for nonlinear systems, but it is often limited by the substantial computational demands of solving a nonlinear optimization problem at every sampling step. To address this issue, we develop an effic...

A Scoring System Contributing to the Detection of Radiation Pneumonitis in Elderly Patients with Lung Cancer—Results of the POLCAR Trial

Background/Objectives: A symptom-based scoring system (0–9 points) for the identification of radiation pneumonitis was previously evaluated in lung cancer patients without age restrictions. A threshold of five points appeared optimal to detect pneumonitis. Since elderly patients...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Incident psoriasis in atopic dermatitis: a large-scale cohort study of disease- and treatment-associated risks

Abstract Background Clinical and genetic evidence on the association between atopic dermatitis (AD) and subsequent psoriasis remains conflicting, and it is unclear whether this risk is modified by systemic treatments. Recent reports suggest type 2-targeted biologics may unmask ps...

Introduction and validation of OSCAR—optimal stent choice algorithm

Abstract Purpose Standardization and international guidelines for stent size selection are lacking. In this study, we introduce and validate an artificial intelligence (AI)- and image processing-supported, modular software algorithm trained on a multicentric vascular segmentation...