Institute for Integrative and Experimental Genomics

A Scoring System Contributing to the Detection of Radiation Pneumonitis in Elderly Patients with Lung Cancer—Results of the POLCAR Trial

Background/Objectives: A symptom-based scoring system (0–9 points) for the identification of radiation pneumonitis was previously evaluated in lung cancer patients without age restrictions. A threshold of five points appeared optimal to detect pneumonitis. Since elderly patients...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Incident psoriasis in atopic dermatitis: a large-scale cohort study of disease- and treatment-associated risks

Abstract Background Clinical and genetic evidence on the association between atopic dermatitis (AD) and subsequent psoriasis remains conflicting, and it is unclear whether this risk is modified by systemic treatments. Recent reports suggest type 2-targeted biologics may unmask ps...

Introduction and validation of OSCAR—optimal stent choice algorithm

Abstract Purpose Standardization and international guidelines for stent size selection are lacking. In this study, we introduce and validate an artificial intelligence (AI)- and image processing-supported, modular software algorithm trained on a multicentric vascular segmentation...