Institute for Biomedical Engineering

Multi-objective computational design optimization of a Total Disc Replacement implant

Abstract While cervical arthroplasty using Total Disc Replacement (TDR) implants is an established treatment for persistent neck and arm pain, revision rates limit it from reaching its full potential. To address the underlying complications, we developed finite element simulation...

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

Using the Stressor-System-Resilience Resources-Outcomes (SSRO) scaffold to clarify the core components of resilience research in medicine

Abstract Modern medicine increasingly extends beyond treating disease to supporting individuals through recovery, adaptation, and long-term functioning, all central to the concept of resilience. Despite growing interest, resilience remains conceptually difficult to structure and...

Support effects and design rules for enhanced phosphotungstic acid catalyzed olefin oligomerization to sustainable aviation fuels

Reducing the environmental footprint of aviation fuels requires catalysts that convert renewable olefins to jet-fuel hydrocarbons (JF). In this context, supported phosphotungstic acid (PTA) emerged as a promising Brønsted acid catalyst for this transformation. The performance of...

Accelerated carbonation of recycled concrete aggregates: Binding of CO2 and decalcification of calcium-silicate-hydrate

Recycled concrete aggregates (RCA) are a valuable resource for reuse as aggregates in concrete and asphalt. However, the porous mortar adhering to the original aggregates and microcracks both in the mortar and at the interfaces result in increased water absorption and reduced mec...

Reduced Complexity Model Intercomparison Project phase 3: experimental protocol for coordinated constraining and evaluation of reduced-complexity models

Abstract. Reduced-Complexity Models (RCMs) are a critical tool for synthesising climate science knowledge and providing climate projections for a wide range of emissions scenarios. The Reduced-Complexity Model Intercomparison Project (RCMIP) provides a framework for the coordinat...

Toward continuous shrinkage measurement of poured earth: practical setup and underlying shrinking mechanisms

Abstract Continuous shrinkage measurement in earth-based materials remains technically challenging, particularly for high-water-content mixtures with low initial stiffness. In this study, a semi-cylindrical experimental setup, combined with digital image correlation (DIC) for mea...

Not just alignment: body shape influences adult spinal deformity biomechanics

Abstract Purpose Adult spinal deformity (ASD) alters sagittal alignment and trunk centre of mass location, increasing spinal loading. Current clinical assessment of ASD primarily focuses on alignment parameters disregarding patient’s body shape variability. This study aimed to ev...