Institut thématique Génétique, génomique et bioinformatique

Chloramphenicol-mobilized Bacillus subtilis transiently expresses resistance to multiple antibiotics, including the glycopeptides phleomycin and bleomycin

ABSTRACT Antibiotic resistance presents an urgent global crisis, exacerbated by antibiotic overuse. Understanding the regulation of resistance genes within bacterial populations can inform strategies to prevent the spread of antibiotic resistance, and reveal how antibiotics shape...

Maternal Tuberculosis and Infant Gut and Immune Development: Implications for Maternal-Child Health

BACKGROUND: Maternal tuberculosis (TB) during pregnancy involves chronic infection, immune activation, and antimicrobial therapy, which may alter the maternal gut, vaginal, and breast milk microbiomes and influence neonatal immune development. METHODS: We conducted a narrative re...

Genomic signatures of selection are enriched in differentially expressed genes in sticklebacks adapting to contrasting environments

Abstract Whole genome scans have identified numerous adaptive alleles in many species; however, linking these alleles to specific phenotypes remains a major challenge. A promising alternative to direct genotype–phenotype mapping, particularly given the complexities introduced by...

Minimal organism JCVI-syn3.0, an engineered derivative of Mycoplasma mycoides , encodes an assortment of unrecognized membrane transporters and immunity factors

ABSTRACT In 2016, researchers at the J. Craig Venter Institute produced JCVI-Syn3.0, a derivative of Mycoplasma mycoides subsp. capri Large Colony strain GM12 with a re-engineered, minimized genome. The minimal synthetic genome of 532 kbp encodes 473 genes, selected from ∼910 par...

Metabolomic fingerprinting from dried blood spots enables individual identification across 1,257 participants at 94% user-level accuracy

Abstract Background Constructing digital twins in healthcare requires biological data sources that are simultaneously informative, dynamic, and practical for routine collection. Dried blood spot (DBS) sampling combined with untargeted metabolomics is well suited to meet these req...