Institut Pasteur de Lille

Chaperone-inspired nanobodies enable pathway-selective control of Tau self-assembly

Abstract Selective control of pathogenic protein self-assembly remains a major challenge for intrinsically disordered amyloid-forming proteins such as Tau. Here we show that nanobodies originally raised against the chaperone S100B unexpectedly cross-react with Tau as potential pa...

Exploring the spatial distribution of biomolecules in Pseudomonas aeruginosa biofilms formed on PDMS and lung explants by mass spectrometry imaging

Bacterial biofilms constitute a form of collective organization that enhances bacterial tolerance to both antibiotics and immune defences. Among bacteria, Pseudomonas aeruginosa (P. aeruginosa) is a major opportunistic pathogen, with marked biofilm-forming capacity, highly implic...

Glycans located upstream of the furin cleavage site in SARS-CoV-2 Spike protein influence its processing and functions

The SARS-CoV-2 Spike (S) glycoprotein, which plays a central role in viral entry, consists of two subunits: S1, which mediates binding to the ACE2 receptor; and S2, which induces fusion of the viral envelope with the cell membrane. The S glycoprotein also contains a polybasic mot...

Use of cardiac magnetic resonance imaging after hospitalization for acute heart failure: insights from the French nationwide OFICA-2 cohort

Abstract Background Cardiac magnetic resonance (CMR) has a central role in the management of patients with acute heart failure (AHF), but timely access remains heterogeneous. We investigated real-world CMR use in patients hospitalized for AHF and its associations with demographic...

Polymer-Driven Self-Templated Synthesis of Boronate-COF Hollow Spheres: Toward the Development of Size-Selective Nanoreactors

Abstract Covalent organic frameworks are a family of porous crystalline structures gaining attention due to their promising applications. However, despite significant efforts, the synthesis and understanding of uniform and specific morphologies remain a challenge. Herein, we repo...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...