Institut Pasteur de Lille

Polymer-Driven Self-Templated Synthesis of Boronate-COF Hollow Spheres: Toward the Development of Size-Selective Nanoreactors

Abstract Covalent organic frameworks are a family of porous crystalline structures gaining attention due to their promising applications. However, despite significant efforts, the synthesis and understanding of uniform and specific morphologies remain a challenge. Herein, we repo...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...